Archives of Dermatology
 1989
DOI: 10.1001/archderm.125.9.1209
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Detection of hepatotoxicity associated with methotrexate therapy for psoriasis

George O'connor1
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“…The pathogenesis of cumulative methotrexate hepatotoxicity is not completely understood. Studies have shown that the pathologic fibrotic changes observed with methotrexate treatment are mostly non-aggressive[ 14 ] and potentially reversible after withdrawal of methotrexate treatment, defined as a period of 6 months or more without administration of methotrexate. [ 15 ] Moreover, a systematic review of liver abnormalities in patients with psoriasis on methotrexate showed that cumulative dose and duration of methotrexate therapy were not associated with fibrosis/cirrhosis on biopsy (as independent variables).…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The pathogenesis of cumulative methotrexate hepatotoxicity is not completely understood. Studies have shown that the pathologic fibrotic changes observed with methotrexate treatment are mostly non-aggressive[ 14 ] and potentially reversible after withdrawal of methotrexate treatment, defined as a period of 6 months or more without administration of methotrexate. [ 15 ] Moreover, a systematic review of liver abnormalities in patients with psoriasis on methotrexate showed that cumulative dose and duration of methotrexate therapy were not associated with fibrosis/cirrhosis on biopsy (as independent variables).…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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