Detection of Epstein-Barr Viral RNA in Malignant Lymphomas of the Upper Aerodigestive Tract

Chan, John K.; Yip, Timothy T.C.; Tsang, William Y.W.; Ng, C.S.; Lau, W.S.; Poon, Y.F.; Wong, Cesar C.s.; W.S., Victor

doi:10.1097/00000478-199409000-00009

Cited by 164 publications

(65 citation statements)

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“…34,35 In situ hybridization of EBERs, which are noncoding mRNAs produced in abundance in all cells latently infected with EBV, is a highly sensitive technique for demonstrating the presence of EBV in tumors and can be performed on routinely fi xed, paraffi n-embedded tissues. 36 This technique also has the advantage of allowing precise localization of EBV infection within specifi c cells. 37 In our case, strong nuclear EBER signals were observed in almost all lymphoma cells; thus, we considered that the EBV infection was directly associated with the CD56+ NK/T-cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis

et al. 2008

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A case of primary NK/T-cell lymphoma of the rectum accompanied with ulcerative colitis (UC) in a 73-year-old man is reported. He had a 6-year history of repeated admission to our hospital for UC. Total colonoscopy performed 4 months after resolution of refractory UC complicated by cytomegalovirus colitis showed a markedly submucosal tumor in the rectum, which was histologically diagnosed as malignant lymphoma. The findings of computed tomography of the chest and abdomen, gallium scintigraphy, abdominal ultrasonography, and upper gastrointestinal endoscopy showed no abnormal lesions. Therefore, based on a diagnosis of localized rectal lymphoma with UC, proctocolectomy was performed. The resected specimen showed three submucosal tumors in the rectum with local nodal involvement. Histologically, the tumors were characterized by diffusely infiltrating sheets of large atypical lymphoid cells, which were negative for CD4, CD8, and CD20 but were positive for CD56, CD3, and granzyme B. The presence of Epstein-Barr virus (EBV) infection in neoplastic cells was shown by in situ hybridization for EBV-encoded early small RNA1 (EBER-1). Based on these findings, the patient was diagnosed with primary CD56+ NK/T-cell lymphoma of the rectum (stage IIE). This is the first case report of primary rectal NK/T-cell lymphoma accompanied with UC.

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Section: Discussionmentioning

confidence: 99%

Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis

et al. 2008

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“…In recent years, the spectrum of CTCLs has been widened by more precise observations and the recognition of new diagnostic categories such as blastic NK-cell lymphoma, 10,11,15,19,21,30,33,67,71 nasal-type extranodal NK/T-cell lymphoma, 16,17,18,20,44,50,62 primary cutaneous aggressive CD8+ epidermotropic T-cell lymphoma, 1,9,32 cutaneous ␥/␦ T-cell lymphoma, 8,29,47,49,64,85,86 and SPTCL. 12,35,43,90,92 These lymphomas originate from cytotoxic T lymphocytes, NK cells, and myeloid-NK cell precursors, and can either arise within the skin as primary cutaneous lymphomas or spread to the skin as secondary manifestations of extracutaneous lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Massone

Chott²,

Metze³

et al. 2004

American Journal of Surgical Pathology

214

180

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A new group of subcutaneous, natural killer (NK), NK/T-cell, and other cytotoxic T-cell lymphomas of the skin has been recently described, and some have been included as distinct clinicopathologic entities in the classification of hematologic malignancies recently proposed by the World Health Organization. In the European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas, they would be classified either as CD30- large T-cell lymphoma, small/medium pleomorphic T-cell lymphoma, or subcutaneous T-cell lymphoma. Precise clinicopathologic and prognostic features of all of them have not yet been well characterized. We studied retrospectively 81 biopsies from 50 patients with subcutaneous, blastic natural killer (NK), NK/T-cell, or other non-mycosis fungoides cytotoxic T-cell lymphomas of the skin. Clinical, morphologic, phenotypical, and genetic features and data on Epstein-Barr virus association allowed us to classify our cases according to the following 7 categories: a) subcutaneous "panniculitis-like" T-cell lymphoma (SPTCL): 10 cases (estimated 5-year survival: 80%); b) blastic NK-cell lymphoma: 12 cases (estimated 5-year survival: 0%); c) nasal-type extranodal NK/T-cell lymphoma: 5 patients (estimated 5-year survival: 0%); d) epidermotropic CD8+ T-cell lymphoma: 5 cases (estimated 5-year survival: 0%); e) cutaneous gamma/delta T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); f) cutaneous alpha/beta pleomorphic T-cell lymphoma: 8 cases (estimated 5-year survival: 0%); and g) cutaneous medium/large pleomorphic T-cell lymphoma, not otherwise specified: 2 cases. Our study shows that these cutaneous lymphomas can be classified according to precise diagnostic categories. With the exception of SPTCL, analysis of follow-up data from our patients showed that these groups of lymphomas are characterized by an aggressive course, regardless of the diagnostic category.

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“…Extranodal NK/T-cell lymphoma has a high association with Epstein-Barr infection. 3,[12][13][14][15][16] This testing, therefore, supported the presumed diagnosis.…”

Section: Discussionmentioning

confidence: 79%

Nasal-type NK/T-cell Lymphoma Presenting as Hemophagocytic Syndrome in an 11-year-old Mexican Boy

Brodkin

Hobohm²,

Nigam³

2008

Journal of Pediatric Hematology/Oncology

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Recently established by the World Health Organization classification, "nasal" and "nasal-type" NK/T-cell lymphoma arise from natural killer (NK) cells. They have distinct clinicopathologic features, specific genotype and phenotype, and a high association with Epstein-Barr virus infection. Nasal-type NK/T-cell lymphoma arise from extranasal sites including skin, soft tissue, gastrointestinal tract, liver, spleen, testes, lung, and central nervous system. Most cases are reported from Asia and South America in adults. There are very few cases reported in the pediatric age group. We report an 11-year-old child with extranodal nasal-type NK/T-cell lymphoma presenting as hemophagocytic syndrome and multiorgan system failure with fatal outcome.

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Detection of Epstein-Barr Viral RNA in Malignant Lymphomas of the Upper Aerodigestive Tract

Cited by 164 publications

References 0 publications

Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis

Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis

Subcutaneous, Blastic Natural Killer (NK), NK/T-cell, and Other Cytotoxic Lymphomas of the Skin: A Morphologic, Immunophenotypic, and Molecular Study of 50 Patients

Nasal-type NK/T-cell Lymphoma Presenting as Hemophagocytic Syndrome in an 11-year-old Mexican Boy

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