Detection of Borrelia burgdorferi DNA (B garinii or B afzelii) in Morphea and Lichen Sclerosus et Atrophicus Tissues of German and Japanese but Not of US Patients

Lichenoid eruptions in children

“…In fact, there is a stronger correlation with certain HLA types in children with LScl than in adult patients with LScl. 88 There is also a controversial correlation between LScl and Borrelia burgdorferi infection, 89,90 and a reported positive correlation between LScl and human papillomavirus in the LScl lesions. 91 It was previously thought that the disease spontaneously resolved at puberty, however, subsequent studies have disputed this claim.…”

Borrelial Lymphocytoma and Acrodermatitis Chronica Atrophicans

“…Rarely, Borrelia have been isolated on culture from CS and LSA lesions in central Europe (Aberer et al, 1987;Weber et al, 1988;Breier et al, 1999;Breier et al, 2001). In Europe and Japan, Borrelia-specific DNA was amplified by PCR from the skin of 25 of a total of 165 (15%) CS patients, and 21 (40%) of 52 LSA patients (Fujiwara et al, 1997;Goodlad et al, 2002). In contrast, PCR for Borrelia sp.…”

“…In contrast, PCR for Borrelia sp. was always negative in US patients (Fan et al, 1995;Fujiwara et al, 1997;Colome-Grimmer et al, 1997). The studies with negative PCR results were more rigorous in that they investigated larger numbers of patients and applied more than one primer set.…”

Lichen sclerosus in the genitourinary region

“…So wurde in europäischen Studien mittels Polymerasekettenreaktion genetisches Material von Borrelia burgdorferi in LS-Präparaten gefunden. Dies konnte jedoch nicht in amerikanischen Studien bestätigt werden [13,17]. Darüber hinaus werden Borrelieninfektionen als möglicher Trigger zur LS-Entstehung bei genetisch empfängli-chen Menschen diskutiert.…”