Abstract:Background: Imatinib is now the standard therapy for newly diagnosed CML patients. However, some patients develop resistance, mainly those treated in advanced stages. Mutations in the kinase domain of BCR/ABL are the most frequent mechanisms associated to resistance in vivo and some of them do not respond even to other kinase inhibitors (nilotinib and dasatinib).
Aims: detect mutations in the kinase domain of BCR/ABL in CML patients with primary or secondary resistance to Imatinib and describe t… Show more
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