2002
DOI: 10.1530/eje.0.1470767
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Abstract: Objective: Several reports have described antipituitary antibodies by immunofluorescent or immunoblotting methods in patients with lymphocytic hypophysitis. However, with the exception of the pituitary hormones, individual antigens specific for the pituitary gland have not been studied. To understand the pathogenesis of lymphocytic hypophysitis and to diagnose this disease efficiently, we studied the presence of autoantibodies against three pituitary-specific proteins, GH and two novel pituitary-specific prote… Show more

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Cited by 87 publications
(58 citation statements)
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References 26 publications
(19 reference statements)
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“…Hyperprolactinemia may develop as a result of stalk compression, presenting with amenorrhea/galactorrhea in females and decreased libido in males (1). DI may result from inflammatory destruction and/or compression of the posterior pituitary or stalk (38). All our patients had macroadenomas and headache was the most common symptom, similar to the literature.…”
Section: Patientsupporting
confidence: 84%
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“…Hyperprolactinemia may develop as a result of stalk compression, presenting with amenorrhea/galactorrhea in females and decreased libido in males (1). DI may result from inflammatory destruction and/or compression of the posterior pituitary or stalk (38). All our patients had macroadenomas and headache was the most common symptom, similar to the literature.…”
Section: Patientsupporting
confidence: 84%
“…Headache is the first and most common symptom (16). Pituitary function is commonly affected in inflammatory hypophysitis, where ACTH and TSH deficiencies are the most frequently reported anomalies (6,15,18,38). Hyperprolactinemia may develop as a result of stalk compression, presenting with amenorrhea/galactorrhea in females and decreased libido in males (1).…”
Section: Patientmentioning
confidence: 99%
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“…Factor 1a, now classified as chromosome 19 open reading frame 30, was expressed in vitro and reported to be recognized only minimally by hypophysitis sera (1 of 17, 6%), isolated ACTH deficiency (2 of 10, 20%), and other autoimmune diseases (1 of 31, 3%) [8]. Factor 2 showed a similar low recognition in that study population [8].…”
Section: Candidate Pituitary Autoantigensmentioning
confidence: 80%
“…Sequencing of this band yielded a nonapeptide fragment that corresponds to either the pituitary GH1 or the placental GH2. When Tanaka and colleagues expressed in vitro the full-length GH1, however, they reported a low recognition in hypophysitis (2 of 17, 12%), isolated ACTH deficiency (1 of 10, 10%), and other autoimmune diseases (2 of 31, 6%) [8].…”
Section: Candidate Pituitary Autoantigensmentioning
confidence: 99%