1987
DOI: 10.1159/000195314
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Detection of Antibodies in Serum of Patients with Idiopathic Pulmonary Fibrosis against Isolated Rat Alveolar Type II Cells

Abstract: The serum of 2 patients suffering from idiopathic pulmonary fibrosis (IPF) repeatedly demonstrated a positive antibody reaction against rat alveolar type II cells isolated by the use of a combination of elastase and trypsin for disaggregation and a Percoll density gradient for purification. Neither of the other 8 IPF patients examined nor any of the controls showed a positive reaction. Because the 2 patients with serum antibodies against alveolar type II cells did not show any antinuclear antibodies, it is con… Show more

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Cited by 6 publications
(7 citation statements)
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References 15 publications
(16 reference statements)
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“…Previous studies have shown that some IPF patients possess circulating autoantibodies to alveolar epithelial cells, 32,33 suggesting a possible autoimmune pathogenesis 29 . The present study provides compelling evidence that a significant number of IPF patients possess autoantibody to alanyl‐tRNA synthetase.…”
Section: Discussionsupporting
confidence: 65%
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“…Previous studies have shown that some IPF patients possess circulating autoantibodies to alveolar epithelial cells, 32,33 suggesting a possible autoimmune pathogenesis 29 . The present study provides compelling evidence that a significant number of IPF patients possess autoantibody to alanyl‐tRNA synthetase.…”
Section: Discussionsupporting
confidence: 65%
“…Previous studies have shown that some IPF patients possess circulating autoantibodies to alveolar epithelial cells, 32,33 suggesting a possible autoimmune pathogenesis. 29 The present study provides compelling evidence that a significant number of IPF patients possess autoantibody to alanyl-tRNA synthetase. On the other hand, autoimmunity to aminoacyl-tRNA synthetase has also been reported in myositis patients, 41,42 particularly in those patients whose disease is complicated with fibrosing alveolitis, Raynaud's phenomenon, and sicca syndrome.…”
Section: Discussionmentioning
confidence: 56%
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“…Even when ANA serology is negative, other autoantibodies may be detectable. In a small cohort of IPF patients, two out of eight patients had persistently positive antibodies against alveolar type II cells, reinforcing the role of epithelial cells in the pathogenesis of IPF 95 …”
Section: Initiation Of Fibrosismentioning
confidence: 75%
“…The main surfactant protein, a peptide with a molecular weight of 28-36 kilodalton depending on its glycosylation, was detected in both cells [23,24]. In a recent study [1] antibodies to isolated rat pneumocytes type II were demonstrated in 20% of patients with idiopathic pulmonary fibrosis.…”
Section: Discussionmentioning
confidence: 99%