Detection and Localization of Early Lung Cancer by Imaging Techniques*

Palcic, Branko; Lam, Stephen; Hung, Jaclyn Y.; MacAulay, Calum

doi:10.1378/chest.99.3.742

Cited by 162 publications

(94 citation statements)

References 7 publications

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“…However, with suitable instrumentation the tissue autofluorescence can be visualized. 25 The intensity of the autofluorescence differs substantially between normal and tumorous tissues, which allows visualization of cancers and precancerous lesions in bronchi. [26][27][28][29] The LIFE system, which was designed by Lam et al, in Vancouver, British Columbia, Canada, 28,30 consists of a light source (helium-cadmium laser, wavelength 442 nm), image intensifier (charge-coupled device [CCD] camera with green and red filters), and imaging console.…”

Section: Development Of Afbmentioning

confidence: 99%

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Wang

et al. 2013

Respir Care

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SummaryBronchoscopy technology is a desirable method for detecting lung cancers arising in the central airways. Most early cancers and precancerous lesions are not visible on conventional white-light bronchoscopy (WLB). Autofluorescence bronchoscopy (AFB) is a newly developed technology that exploits the difference in autofluorescence intensity between normal and tumorous tissues to detect bronchial cancers and precancerous lesions. Several types of AFB systems have been used in clinical practice, and autofluorescence imaging videobronchoscopy (AFI) is one of these AFBs. In most of the studies on AFB other than AFI, AFB has provided a much higher sensitivity but a lower specificity than WLB. Regarding AFI, recent studies have reported controversial results on the sensitivity and specificity for detecting cancers and precancerous lesions, compared with WLB. In this paper we describe the working mechanisms and characteristics of AFBs, mainly AFI, and the diagnostic performance of AFI, compared with WLB, other AFBs, and narrow-band imaging, for detecting lung cancers and precancerous lesions. Key words: autofluorescence imaging videobronchoscopy; autofluorescence bronchoscopy; white-light bronchoscopy; narrow-band imaging; lung cancer; precancerous lesion. [Respir Care 2013;58(12):2150 -2159

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Section: Development Of Afbmentioning

confidence: 99%

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Wang

et al. 2013

Respir Care

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“…One is to incorporate a point-measuring device with spectral resolution into an imaging instrument, so that any suspicious region on the image can be investigated spectroscopically (Hirano et al 1989). Another is to perform sequential or parallel imaging at several excitation or emission wavelengths to subtract autofluorescence or to form wavelength ratios (Profio and Balchum 1985, Profio et al 1986, Baumgartner et al 1987, Wagnières et al 1990, Palcic et al 1991, van den Bergh 1994. One of these systems, detecting two images in two emission bands, has been developed to a commercial product especially for endoscopic applications (Xillix Techn.…”

Section: Fluorescence Imaging Techniquesmentioning

confidence: 99%

“…The diagnostic capability of this system, is based on the ratio between a red and a green autofluorescence emission band. The technique is reported to produce results of clinical interest in certain specialities (Lam et al 1991, 1993a, b, Harris et al 1995. The technique is therefore also approved by FDA for routine clinical use for endoscopic lung cancer examinations using the pure tissue autofluorescence.…”

Section: Fluorescence Imaging Techniquesmentioning

confidence: 99%

In vivofluorescence imaging for tissue diagnostics

et al. 1997

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In vivo fluorescence imaging for tissue diagnosticsAndersson-Engels, Stefan; af Klinteberg, C; Svanberg, Katarina; Svanberg, Sune General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract. Non-invasive fluorescence imaging has the potential to provide in vivo diagnostic information for many clinical specialities. Techniques have been developed over the years for simple ocular observations following UV excitation to sophisticated spectroscopic imaging using advanced equipment. Much of the impetus for research on fluorescence imaging for tissue diagnostics has come from parallel developments in photodynamic therapy of malignant lesions with fluorescent photosensitizers. However, the fluorescence of endogenous molecules (tissue autofluorescence) also plays an important role in most applications. In this paper, the possibilities of imaging tissues using fluorescence spectroscopy as a mean of tissue characterization are discussed. The various imaging techniques for extracting diagnostic information suggested in the literature are reviewed. The development of exogenous fluorophores for this purpose is also presented. Finally, the present status of clinical evaluation and future directions are discussed. In vivo fluorescence imaging for tissue diagnostics

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“…[12][13][14][15][16][17][18][19][20][21][22][23][24] Images are also much easier to interpret for the examining doctor than results presented from selected positions. For some applications exogenous substances providing high fluorescence signals can be utilized.…”

Section: Introductionmentioning

confidence: 99%

Compact medical fluorosensor for minimally invasive tissue characterization

Klinteberg

Andreasson

Sandström

et al. 2005

Review of Scientific Instruments

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A compact fiber-optic point-measuring fluorosensor fully adapted to clinical studies is described. The system can use two excitation wavelengths, 337 and 405nm, obtained from a nitrogen laser directly, or after dye laser conversion, respectively. The image intensifier used in the spectrometer can be gated with a variable time delay, allowing also time-resolved spectra to be extracted, with a time resolution of about 4ns. Moreover, diffusely scattered white light can be spectrally recorded. The system is fully computer controlled enabling short recording times in clinical application, which are illustrated.

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Detection and Localization of Early Lung Cancer by Imaging Techniques*

Abstract: FIGURE 1. In vivo autofluorescence spectra of normal bronchus and carcinoma in situ induced by a helium-cadmium laser (442 nm wavelength, 17 mW).

Cited by 162 publications

References 7 publications

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

In vivofluorescence imaging for tissue diagnostics

Compact medical fluorosensor for minimally invasive tissue characterization

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