Detection and identification of designer drugs by nanoparticle-based NMR chemosensing

Abstract

Unknown designer drugs can be recognized by self-organized nanoparticle receptors and identified by magnetization transfer NMR.

The role of nanoparticle size and ligand coverage in size focusing of colloidal metal nanoparticles

“…BL ligandÀparticle reversible binding (4) k 1-f and k 1-r are the forward and reverse rate constants for ligand-precursor reversible binding, eqn (1). k 2-nuc and k 3-growth are the rate constants of reduction/nucleation, eqn (2), and autocatalytic surface growth, eqn (3), respectively.…”

“…Colloidal synthesis offers a versatile bottom-up approach and has been constantly advancing over the past few decades, with better control over size, shape, composition, super-lattice structure and consequently the nanoparticles' properties (catalytic, electronic, optical, etc.). [1][2][3][4][5][6] For example, recent synthetic methods enabled fabrication of colloidal nanoparticles with different sizes by simply altering the reaction conditions (solvent, ligand, precursor, and synthesis temperature). [7][8][9][10][11] However, since the size distribution of the nanoparticles is oen key to their specic, desired physical and chemical properties, [12][13][14][15][16][17][18] a fundamental understanding of how to control the nucleation and growth is key to enable predictive synthesis of nanoparticles with the desired properties.…”

Molecular‐Dynamics‐Simulation‐Directed Rational Design of Nanoreceptors with Targeted Affinity

“…DLS and DOSY‐NMR experiments confirmed the absence of relevant aggregation. The affinity of the nanoparticles for salicylate was investigated by 1 H NOE‐pumping spectroscopy ,,. This experiment employs a diffusion filter to retain only the magnetization stemming from the nanoparticle spins, which is subsequently transferred via NOE only to those molecules in long‐lived interaction with the nanoparticle surface.…”

Multimodal 19F NMR Dopamine Detection and Imaging with a Nanoparticle‐Based Displacement Assay

“…19 FNMR spectrao f3,4@1-AuNp ([1-AuNp] = 8.57 mm, [3] = 85 mm, [4] = 85 mm,0 .001 %N aOD, [D 6 ]DMSO) before(a) and after (b) the additiono f6 and 9 (80 and 120 mm, respectively). c, d) 19 FNMR spectraof3,4,5@1-AuNp ([1-AuNp] = 8.57 mm, [3] = 60 mm, [ 4] = 60 mm, [ 5] = 120 mm,0 .001 %N aOD, [D 6 ]DMSO) before(c) and after (d) the addition of 6 (600 mm).…”

“…Discriminative chemosensors based on NMR spectroscopy have emerged as an alternativet ool for multianalyte detec-tion. [5][6][7] Such systemst urn the cross-reactivity problem into a benefitd ue to the production of ad ifferent signal for each analyte detected. Particular attention has been received by systems that generate 19 FNMR signals.…”