volume 12, issue 8-12, P2978 2007
DOI: 10.2741/2287
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Abstract: Fabricated solid-state nanopore chips are used to probe individual single stranded DNA (ssDNA) homopolymers. Based on the analysis of the current blockage caused by DNA translocation through a voltage-biased nanopore, we discovered that the hydrodynamic diameter of ssDNA homopolymer helix is comparable to that of double stranded DNA (dsDNA) helix. This proof-of-principle demonstration shows that solid-state nanopore technology can be used to spy on secondary structures of biopolymers. We also show that ssDNA m…

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