Detecting Obstructive Coronary Disease With CT Angiography and Noninvasive Fractional Flow Reserve

The value of fractional flow reserve based on coronary computed tomography angiography with low-dose contrast agent in noninvasive diagnosis of coronary artery disease

“…According to Patel [22], noninvasive technologies such as FFRCT + CT may move the clinical community closer to the holy grail of a high-quality combined anatomic and functional test for the detection of CAD that improves efficiency and patient outcomes.…”

Coronary plaque quantification and fractional flow reserve by coronary computed tomography angiography identify ischaemia-causing lesions

“…Over the past decades, an optimal non-invasive imaging modality combining anatomy and physiology with the ability to serve as a ‘one-stop shop’ for the diagnosis of ischaemia and gatekeeping to ICA has been requested. 30 FFR CT , a novel clinical tool for non-invasive and reproducible computation of FFR from standard coronary CTA, 12 , 31 has been evaluated in three studies using FFR as the reference standard. 13–15 The most recent NXT trial performed with refined FFR CT technology demonstrated superior per-patient and per-vessel discrimination of ischaemia of FFR CT when compared with coronary CTA stenosis assessment.…”

Effect of the Coronary Arterial Diameter Derived From Coronary Computed Tomography Angiography on Fractional Flow Reserve

“…Considering that FFR is of primary importance, it is crucial to acknowledge all potential bias during the assessment, such as in the study of Kwasiborski et al 11 who studied the effect of heart rate on FFR. In recent years, with the development of computational fluid dynamics, personalized hemodynamics simulation based on medical imaging and noninvasive numerical computation of FFR has become a reality, thus providing a new noninvasive method for the functional determination of coronary artery stenosis 12–23 . CT-based computation of non-invasive fractional flow reserve (FFR CT ) is a noninvasive indicator for the diagnosis of functional ischemia.…”

“…In recent years, with the development of computational fluid dynamics, personalized hemodynamics simulation based on medical imaging and noninvasive numerical computation of FFR has become a reality, thus providing a new noninvasive method for the functional determination of coronary artery stenosis. [12][13][14][15][16][17][18][19][20][21][22][23] CT-based computation of non-invasive fractional flow reserve (FFR CT ) is a noninvasive indicator for the diagnosis of functional ischemia.…”