Detecting liver injury non‐invasively using hyperpolarized ¹³C MRI

Abstract

See Article on Page 1117

Redox-Activated Contrast-Enhanced T1-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver

“…In vivo visualization of GSH-mediated biotransformation offers a promising method for in-depth investigations of these processes in liver that may have not been well studied before. Due to the aforementioned reasons, in vivo real-time visualization techniques for GSH-mediated biotransformation are in great demand in both biomedical research and clinical practice. − Recently, several fluorescence-based imaging methods have been developed, − including a fluorescent imaging technique based on thiol-activatable gold nanoprobes, which accomplished in vivo monitoring of GSH-mediated biotransformation at the molecular level and indicated that this process can be used to modulate the in vivo transport of nanoparticles. , However, the shortcomings of current fluorescence imaging, such as restricted penetration depth, significant autofluorescence interference, and limited anatomical information, impose substantial difficulties for further popularization of these fluorescence-based imaging techniques.…”