Detecting changes during pregnancy with Raman spectroscopy

Vargis, Elizabeth; Robertson, Kesha; Al-Hendy, Ayman; Reese, Jeff; Mahadevan‐Jansen, Anita

doi:10.1117/12.843005

Cited by 2 publications

(3 citation statements)

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“…38 Trends early in pregnancy followed a “logical process”, but those late in pregnancy were difficult to recognize, “without a clear pattern”. Much greater variation was noted in a pilot study in humans.…”

Section: Approaches To Assesssment Of Cervical Microstructurementioning

confidence: 99%

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Beyond cervical length: emerging technologies for assessing the pregnant cervix

Feltovich

Hall

Berghella

2012

American Journal of Obstetrics and Gynecology

133

113

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Spontaneous preterm birth is a heterogeneous phenotype. A multitude of pathophysiologic pathways culminate in the final common denominator of cervical softening, shortening and dilation that leads to preterm birth. A precise description of specific microstructural changes to the cervix is imperative if we are to identify the causative upstream molecular processes and resultant biomechanical events associated with each unique pathway. Currently, however, we have no reliable clinical tools for quantitative and objective evaluation, which likely contributes to the reason the singleton spontaneous preterm birth rate has not appreciably changed in more than 100 years. Fortunately, promising techniques to evaluate tissue hydration, collagen structure and/or tissue elasticity are emerging. These will add to the body of knowledge about the cervix and facilitate coordination of molecular studies, ultimately leading to novel approaches to preterm birth prediction and, finally, prevention.

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Section: Approaches To Assesssment Of Cervical Microstructurementioning

confidence: 99%

“…Also, the authors note that the significant variability noted in women could “hinder” the “ability to find clear Raman shifts of statistical significance”. 38 …”

Section: Approaches To Assesssment Of Cervical Microstructurementioning

confidence: 99%

Beyond cervical length: emerging technologies for assessing the pregnant cervix

Feltovich

Hall

Berghella

2012

American Journal of Obstetrics and Gynecology

133

113

View full text Add to dashboard Cite

show abstract

“…Preclinical experiments have shown that techniques to measure propagation velocity of low frequency elastic waves (i.e. shear wave speed) and quantitative analysis of the microstructure (Raman spectroscopy and backscattered power loss) are promising for future clinical use. Herein, we aimed to review those methods that have already been applied in vivo on the human cervix hence are closer to clinical application.…”

Section: Introductionmentioning

confidence: 99%

In vivo assessment of the biomechanical properties of the uterine cervix in pregnancy

et al. 2013

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Measuring the stiffness of the cervix might be useful in the prediction of preterm delivery or successful induction of labor. For that purpose, a variety of methods for quantitative determination of physical properties of the pregnant cervix have been developed. Herein, we review studies on the clinical application of these new techniques. They are based on the quantification of mechanical, optical, or electrical properties associated with increased hydration and loss of organization in collagen structure. Quasi-static elastography determines relative values of stiffness; hence, it can identify differences in deformability. Quasi-static elastography unfortunately cannot quantify in absolute terms the stiffness of the cervix. Also, the current clinical studies did not demonstrate the ability to predict the time point of delivery. In contrast, measurement of maximum deformability of the cervix (e.g. quantified with the cervical consistency index) provided meaningful results, showing an increase in compliance with gestational age. These findings are consistent with aspiration measurements on the pregnant ectocervix, indicating a progressive decrease of stiffness along gestation. Cervical consistency index and aspiration measurements therefore represent promising techniques for quantitative assessment of the biomechanical properties of the cervix.

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Detecting changes during pregnancy with Raman spectroscopy

Cited by 2 publications

References 0 publications

Beyond cervical length: emerging technologies for assessing the pregnant cervix

Beyond cervical length: emerging technologies for assessing the pregnant cervix

In vivo assessment of the biomechanical properties of the uterine cervix in pregnancy

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