Abstract:The role of positive selection in molecular evolution has long been debated since the proposal of the neutral theory. With the explosive growth of genomic sequence data and aided by statistical methods such as Phylogenetic Analysis by Maximum Likelihood (PAML), recent years witnessed a flurry of reports of positive selection in protein-coding genes. However, with a few exceptions, the reported positively selected sites generally lacked functional data to support them. Restriction enzymes in bacteria are under … Show more
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