Detailed features of hematological involvement and medication-induced cytopenia in systemic lupus erythematosus patients: single center results of 221 patients

Teke, Hava Üsküdar; Korkmaz, Cengiz

doi:10.5152/eurjrheum.2017.160086

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…45 Besides these treatments, there are a few reports on the use of MMF, azathioprine, cyclosporine, and cyclophosphamide for thrombocytopenia in patients refractory to corticosteroids. 8,33,46-48…”

Section: Discussionmentioning

confidence: 99%

“…Uskudar Teke et al reported that renal involvement and antiphospholipid syndrome were detected more frequently in patients with cytopenia at the time of diagnosis, consistent with our findings. 33 They recommended examination for antiphospholipid syndrome (APS) and close monitorization for renal involvement in SLE patients with cytopenia. 33 González-Naranjo et al also reported that aPLs and AIHA were independent risk factors for thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

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Hematological involvement in pediatric systemic lupus erythematosus: A multi-center study

Akça

Batu

Kısaarslan

et al. 2021

Lupus

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Introduction: Systemic lupus erythematosus (SLE) may present with features of several systems, including hematological manifestations. In this study, we aimed to evaluate the characteristics of hematological involvement and assess possible associations and correlations in pediatric SLE patients. Method: This is a retrospective multi-center study. The medical records of pediatric SLE patients followed between January 2000 and June 2020 were analyzed. All children fulfilled the criteria of the Systemic Lupus International Collaborating Clinics. Results: The study included 215 children with SLE, 118 of whom had hematological manifestations. Concomitant renal involvement and low C3 levels were significantly more frequent in patients with hematological involvement ( p = 0.04, p = 0.008, respectively). Also, anti-cardiolipin, anti-beta-2-glycoprotein I (anti-β2 GP1), and anti-Sm antibody positivity, and the presence of lupus anticoagulant were more common in the group with hematological findings ( p = 0.001 for anti-cardiolipin antibody positivity and p < 0.001 for the positivity of anti-β2 GP1 antibody, anti-Sm antibody, and lupus anticoagulant). The most common hematologic abnormality was anemia (n = 88, 74.5%), with autoimmune hemolytic anemia constituting the majority (n = 40). Corticosteroids followed by IVIG were the mainstay of treatment. In patients resistant to corticosteroid and IVIG treatments, the most preferred drug was rituximab. Low levels of C3, high SLEDAI score, high incidence of renal involvement, and positive antiphospholipid antibodies were associated with hematological involvement in the univariate analysis. The presence of antiphospholipid antibodies and high SLEDAI score were independently associated with hematological involvement in multivariate analysis (OR: 4.021; 95% CI: 2.041–7.921; p < 0.001 and OR: 1.136; 95% CI: 1.065–1.212; p < 0.001). Conclusion: Hematological abnormalities are frequently encountered in pediatric SLE. Positive antiphospholipid antibodies and high SLEDAI scores were associated with hematological involvement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hematological involvement in pediatric systemic lupus erythematosus: A multi-center study

Akça

Batu

Kısaarslan

et al. 2021

Lupus

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“…According to morphology, normochromic normocytic anemia in 61 patients (57.55%) was the most frequent hematological manifestation of anemia which is strongly connected to anemia of chronic disease [22]. Similar results by Rouf et al, Usman et al, and Uskudar Teke et al also found SLE patients with normochromic normocytic anemia in most of the sample [7][22] [23] . Long-term inflammation and systemic disease are the most typical causes of normochromic normocytic anemia [24].…”

Section: Resultssupporting

confidence: 61%

The Pattern of Hematological Manifestations in Systemic Lupus Erythematosus Patients at Dr. Soetomo General Academic Hospital Surabaya

Maharani¹,

Yuliasih²,

Notopuro³

et al. 2022

IJRP

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Systemic Lupus Erythematosus (SLE) is an autoimmune illness with a broad range of clinical manifestations, one of which is hematological manifestations that cause high morbidity and mortality if there is a delay in diagnosis. This research was conducted to analyze the pattern of hematological manifestations of SLE patients. This research was a descriptive retrospective study. A total of 106 patients with systemic lupus erythematosus met the inclusion criteria. Patients were dominated by a female (94.34%) and the age group of 18 -27 years old (46.23%). The average hemoglobin level of the sample was 8.16 g/dl with anemia in 99 patients (93.4%), which was morphologically dominated by normochromic normocytic anemia in 61 patients (57.55%). The mean platelet count of the sample was 192.77 x など戴航詣 and thrombocytopenia was found in 26 patients (24.53%). The mean lymphocyte count of the sample was 1.03 x など戴航詣 and lymphopenia was found in 26 patients (79.25%). The mean leukocyte count in the sample was 7.53 x など戴航詣 and leukopenia was found in 22 patients (20.75%). This study concludes that SLE patients are dominated by females aged 18 -27 years old and the most frequent hematological abnormalities are anemia (morphologically dominated by normochromic normocytic anemia), thrombocytopenia, lymphopenia, and leukopenia.

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“…Leukopenia is usually caused by either or both lymphopenia and neutropenia. Low lymphocyte count commonly occurs in SLE, with a prevalence ranging from 15 to 93%, while neutropenia was described in 4.5% to 47% of patients [ 1 , 9 – 12 ]. The significant differences in the prevalence of leukopenia, neutropenia, and lymphopenia among these studies may be related to the number of cases, race, region, treatment, and research method used.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics of Leukopenia in Patients with Systemic Lupus Erythematosus of Han Ethnicity in China: A Cross-Sectional Study

Zhong

Zhang

et al. 2021

Rheumatol Ther

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Introduction: The characteristics of leukopenia in patients with systemic lupus erythematosus (SLE) in different studies are different, which may be related to region, race, and sample size. Moreover, the extent of leukocyte count decline remains to be studied. This study aimed to analyze the clinical characteristics of leukopenia in patients with SLE of Han ethnicity in China. Methods: A single-center, retrospective, crosssectional study was conducted in Chinese Han patients with SLE from June 2013 to August 2020. Results: A total of 125 patients with SLE were included in the study, and 104 age-and sexmatched healthy controls were recruited. The prevalence of leukopenia, neutropenia, and lymphopenia was 40.0, 20.8, and 55.2%, respectively. The median leukocyte count in the leukopenia group was 2.80 9 10 9 /l, the median neutrophil count in the neutropenia group was 1.40 9 10 9 /l, and the median lymphocyte count in the lymphopenia group was 0.60 9 10 9 /l, which was 47.06, 40.58, and 30.00% of the median of the healthy control group, respectively. The lymphocyte count of SLE patients without lymphopenia was also lower than that of healthy controls, and the lymphocyte count was negatively correlated with the SLE disease activity index 2000 score in all patients with SLE. Independent risk factors for neutropenia include decreased platelet count and lymphocyte count, as well as the presentation of cylindruria. For lymphopenia, the independent risk factors were positivity for anti-dsDNA antibody and Coombs' test, decreased platelet count, and cylindruria. Conclusions: In Han Chinese patients with SLE, leukopenia, neutropenia, and lymphopenia are common clinical manifestations, and the degree of reduction in blood cell count was also remarkable. Lymphopenia is associated with disease severity in patients with SLE. The correlation between Coombs' test results and lymphopenia deserves further study.

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Detailed features of hematological involvement and medication-induced cytopenia in systemic lupus erythematosus patients: single center results of 221 patients

Cited by 8 publications

References 13 publications

Hematological involvement in pediatric systemic lupus erythematosus: A multi-center study

Hematological involvement in pediatric systemic lupus erythematosus: A multi-center study

The Pattern of Hematological Manifestations in Systemic Lupus Erythematosus Patients at Dr. Soetomo General Academic Hospital Surabaya

The Clinical Characteristics of Leukopenia in Patients with Systemic Lupus Erythematosus of Han Ethnicity in China: A Cross-Sectional Study

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