The crustal structure of Western Nepal is studied for the first time by performing receiver function analysis on teleseismic waveforms recorded at 16 seismic stations. The Moho geometry is imaged as it deepens from ~40‐km depth beneath the foothills and the Lesser Himalaya to ~58‐km depth beneath the Higher Himalayan range. A midcrustal low‐velocity zone is detected at ~15‐km depth along ~55‐km horizontal distance and is interpreted as the signature of fluids expelled from rocks descending in the footwall of the Main Himalayan Thrust. Our new image allows structural comparison of the Moho and of the Main Himalayan Thrust geometry along‐strike of the Himalayas and documents long‐wavelength lateral variations. The general crustal architecture observed on our images resembles that of Central Nepal; therefore, Western Nepal is also expected to be able to host large (MW > 8) megathrust earthquakes, as the 1505 CE event.