Desquamative rash in an immunocompromised adult. Staphylococcal scalded skin syndrome (SSSS)

Jl, Herzog; Fm, Sexton

doi:10.1001/archderm.126.6.815b

Cited by 6 publications

(1 citation statement)

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“…A histological examination can also rapidly differentiate between SSSS and TEN. Even a sample of the roof of an intact bulla taken to a laboratory in saline‐moistened gauze can be processed for frozen section to histologically demonstrate subcorneal cleavage, but we recommend a skin biopsy.…”

Section: Diagnosismentioning

confidence: 99%

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Handler

Schwartz

2014

Acad Dermatol Venereol

127

135

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Staphylococcal scalded skin syndrome is a potentially life-threatening disorder caused most often by a phage group II Staphylococcus aureus infection. Staphylococcal scalded skin syndrome is more common in newborns than in adults. Staphylococcal scalded skin syndrome tends to appear abruptly with diffuse erythema and fever. The diagnosis can be confirmed by a skin biopsy specimen, which can be expedited by frozen section processing, as staphylococcal scalded skin syndrome should be distinguished from life threatening toxic epidermal necrolysis. Histologically, the superficial epidermis is detached, the separation level being at the granular layer. The diffuse skin loss is due to a circulating bacterial exotoxin. The aetiological exfoliating toxin is a serine protease that splits only desmoglein 1. The exfoliative toxins are spread haematogenously from a localized source of infection, causing widespread epidermal damage at distant sites. Sepsis and pneumonia are the most feared complications. The purpose of this review is to summarize advances in understanding of this serious disorder and provide therapeutic options for both paediatric and adult patients. Recent epidemiological studies have demonstrated that paediatric patients have an increased incidence of Staphylococcal scalded skin syndrome during the summer and autumn. Mortality is less than 10% in children, but is between 40% and 63% in adults, despite antibacterial therapy. Previously, intravenous immunoglobulin had been recommended to combat Staphylococcal scalded skin syndrome, but a recent study associates its use with prolonged hospitalization.

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Section: Diagnosismentioning

confidence: 99%

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Handler

Schwartz

2014

Acad Dermatol Venereol

127

135

View full text Add to dashboard Cite

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Staphylococcal scalded skin syndrome in an immunocompromised adult

Roeb

Schönfelder

Matern

et al. 1996

Eur. J. Clin. Microbiol. Infect. Dis.

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Staphylococcal scalded skin syndrome, a generalized exfoliative dermatitis complicating infections by exfoliative toxin-producing strains of Staphylococcus aureus, is rarely observed in adults. In contrast to mortality in infants, mortality in adults is usually high. A case of generalized staphylococcal scalded skin syndrome in an immunocompromised woman is reported. Culture of skin biopsy and pleural fluid yielded identical strains of staphylococcus aureus belonging to phage group II. Exfoliative toxins A and B were detected in both isolates. As far as can be determined, this is the first reported case of generalized staphylococcal scalded skin syndrome in an adult with detection of exfoliate toxins A and B in which the patient was treated successfully.

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Staphylococcal scalded-skin syndrome in an adult due to methicillin-resistant Staphylococcus aureus

Ito

Yoh

Toda

et al. 2002

Journal of Infection and Chemotherapy

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Desquamative rash in an immunocompromised adult. Staphylococcal scalded skin syndrome (SSSS)

Cited by 6 publications

References 0 publications

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Staphylococcal scalded skin syndrome: diagnosis and management in children and adults

Staphylococcal scalded skin syndrome in an immunocompromised adult

Staphylococcal scalded-skin syndrome in an adult due to methicillin-resistant Staphylococcus aureus

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