Desorption/Ionization on Silicon Nanowires

Go, Eden P.; Apon, Junefredo V.; Luo, Guanghong; Saghatelian, Alan; Daniels, R. Nathan; Sahi, V.; Dubrow, Robert; Cravatt, Benjamin F.; Vertes, Akos; Siuzdak, Gary

doi:10.1021/ac048460o

Cited by 252 publications

(240 citation statements)

References 41 publications

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“…To date a number of ionization techniques that belong to SALDI have been proposed,1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, ...…”

Section: Introductionmentioning

confidence: 99%

“…nanoparticles as typical, in treatable forms such as suspension liquids in order to ensure that the photon energies of the laser can act to desorp and ionize analytes 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45. Indeed, the soft ionization laser method such as the original form of MALDI also belongs to this category 1.…”

Section: Introductionmentioning

confidence: 99%

“…The techniques in the other category utilize planar solid substrates with fine structures on the uppermost surface layer as the target plate, so that the photon energies of the laser can reach analytes which are spread over and adsorbed onto the surface and achieve desorption and ionization of analytes 20, 23, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80. Desorption Ionization on Silicon (DIOS) is the representative technique in this category 46.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A novel laser desorption/ionization method using through hole porous alumina membranes

Naito

Kotani

Ohmura

2018

Rapid Comm Mass Spectrometry

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RationaleA novel matrix‐free laser desorption/ionization method based on porous alumina membranes was developed. The porous alumina membranes have a two‐dimensional (2D) ordered structure consisting of closely aligned straight through holes of sub‐micron in diameter that are amenable to mass production by industrial fabrication processes.MethodsConsidering a balance between the ion generating efficiency and the mechanical strength of the membranes, the typical values for the hole diameter, open aperture ratio and membrane thickness were set to 200 nm, 50% and 5 μm, respectively. The membranes were coated with platinum on a single side that was exposed to the laser. Evaluation experiments were conducted on the feasibility of this membrane structure for an ionization method using a single peptide and mixed peptides and polyethylene glycol samples and a commercial matrix‐assisted laser desorption/ionization (MALDI) time‐of‐flight mass spectrometer in the positive ion mode.ResultsResults showed a softness of ionization and no sweet spot nature. The capillary action of the through holes with very high aspect ratio enables several loading protocols including sample impregnation from the surface opposite to the laser exposure side.ConclusionsThe feasibility study indicates that the through hole porous alumina membranes have several advantages in terms of usefulness over the conventional surface‐assisted laser desorption ionization (SALDI) methods. The proposed novel ionization method is termed Desorption Ionization Using Through Hole Alumina Membrane (DIUTHAME).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel laser desorption/ionization method using through hole porous alumina membranes

Naito

Kotani

Ohmura

2018

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

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“…A number of inorganic materials have been developed as alternative matrixes to avoid the drawbacks of using conventional organic matrixes [10][11][12][13][14][15][16][17]. Although low fragmentation of matrix ions can be attained with these techniques, several experimental factors, including surface morphology and laser fluence, need to be optimized simultaneously to achieve a reliable analysis.…”

Section: Introductionmentioning

confidence: 99%

N-(1-Naphthyl) Ethylenediamine Dinitrate: A New Matrix for Negative Ion MALDI-TOF MS Analysis of Small Molecules

Chen

Xiong

et al. 2012

J. Am. Soc. Mass Spectrom.

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An organic salt, N-(1-naphthyl) ethylenediamine dinitrate (NEDN), with rationally designed properties of a strong UV absorbing chromophore, hydrogen binding and nitrate anion donors, has been employed as a matrix to analyze small molecules (m/zG1000) such as oligosaccharides, peptides, metabolites and explosives using negative ion matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF MS). Compared with conventional matrixes such as α-cyano-4-hydroxycinnamic acid (CCA) and 2,5-dihydroxybenzoic acid (DHB), NEDN provides a significant improvement in detection sensitivity and yields very few matrixassociated fragment and cluster ions interfering with MS analysis. For low-molecular-weight saccharides, the lowest detection limit achieved ranges from 500 amol to 5 pmol, depending on the molecular weight and the structure of the analytes. Additionally, the mass spectra in the lower mass range (m/zG200) consist of only nitrate and nitric acid cluster ions, making the matrix particularly useful for structural identification of oligosaccharides by post-source decay (PSD) MALDI-MS. Such a characteristic is illustrated by using maltoheptaose as a model system. This work demonstrates that NEDN is a novel negative ion-mode matrix for MALDI-MS analysis of small molecules with nitrate anion attachment.

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“…More recently, direct laser desorption/ionization on carbon nanotubes or silicon nanowires has been reported [36,37].…”

Section: Introductionmentioning

confidence: 99%

Surface-assisted laser desorption/ionization-mass spectrometry using TiO2-coated steel targets for the analysis of small molecules

et al. 2011

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Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) measurements in the low-molecular mass region, ranging from 0 to 1000 Daltons are very often difficult to perform because of signal interferences originating from matrix ions. In order to overcome this problem, a stainless steel target was coated with a homogeneous titanium dioxide layer. The layer obtained was further investigated for its ability to desorb small molecules, e.g. amino acids, sugars, polyethyleneglycol (PEG 200) or extracts from Cynara scolymus leaves. The stability of the layer was determined by repeated measurements on the same target location, which was monitored by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) before and after surface assisted laser desorption/ionization (SALDI) analysis. In addition, the titanium dioxide layerwas compared with an already published method with titanium dioxide nanopowder as inorganic matrix. As a result of this work, the titanium dioxide layer produced minimal background interference, enabling simple interpretation of the detected mass spectra. Furthermore, the TiO2 coating provides a target that can be reused many times for SALDI-MS measurements.

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Desorption/Ionization on Silicon Nanowires

Cited by 252 publications

References 41 publications

A novel laser desorption/ionization method using through hole porous alumina membranes

A novel laser desorption/ionization method using through hole porous alumina membranes

N-(1-Naphthyl) Ethylenediamine Dinitrate: A New Matrix for Negative Ion MALDI-TOF MS Analysis of Small Molecules

Surface-assisted laser desorption/ionization-mass spectrometry using TiO2-coated steel targets for the analysis of small molecules

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