Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus

Immunoserological analyses of 55 patients with pemphigus at the Dermatological Department of Kurume University Hospital: an 11‐year retrospective study (1996–2006)

“…Furthermore, our ELISA studies revealed that patients with pemphigus vegetans and pemphigus erythematosus (considered to be subtypes of PV and PF, respectively), produced results comparable to those produced by PV and PF samples. In patients with pemphigus herpetiformis (HP), three patients showed anti‐Dsg1 IgG, confirming previous reports that most HP patients showed anti‐Dsg1 IgG 3 . All patients with PNP showed anti‐Dsg3 IgG, as reported by Amagai et al 4 .…”

Paraneoplastic Pemphigus Herpetiformis With IgG Antibodies to Desmoglein 3 and Without Mucosal Lesions

“…1,7,8 Few patients with PH demonstrate autoantibodies to Dsg3, and our patient's immunologic profile supports the concept that Dsg3 is also a target antigen in this disease. 1,3,[6][7][8] Many of these cases, including our patient, did not have mucosal involvement, and this further reinforces that the pathogenesis of PH autoantibodies differs from that of classic pemphigus and that other unknown factors may be involved.…”

Concurrence of bullous pemphigoid and herpetiform pemphigus with IgG antibodies to desmogleins 1/3 and desmocollins 1-3

“…In our case, a diagnosis of PH was suggested by all clinical, histopathological and immunofluorescence findings. While our previous studies using Dsg1 and Dsg3 ELISA showed that the target antigens of PH were mainly Dsg1 and occasionally Dsg3, 3 anti‐Dsc antibodies were also detected in some cases of PH 4,5 . Therefore, the serological results for autoantigens in our patient were consistent with PH.…”