Designing biocompatible Ti-based metallic glasses for implant applications

Calin, Mariana; Gebert, A.; Ghinea, Andreea Cosmina; Gostin, Petre Flaviu; Abdi, Somayeh; Mickel, C.; Eckert, J.

doi:10.1016/j.msec.2012.11.015

Cited by 193 publications

(123 citation statements)

References 58 publications

(266 reference statements)

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…Compared with conventional Ti alloys, Ti-based BMGs are more suitable for biomedical applications for the following reasons [222,223]: (1) high strength and hardness, which may lead to good loadbearing capability and high wear resistance; (2) low Young's (elastic) …”

Section: Biocompatibility Of Ti-based Bmgsmentioning

confidence: 99%

Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Gong

Deng

Jin

et al. 2016

Metals

View full text Add to dashboard Cite

Abstract:Ti-based bulk metallic glasses (BMGs) are very attractive for applications because of their excellent properties such as high specific strength and high corrosion resistance. In this paper, we briefly review the current status of the research and development of Ti-based bulk metallic glasses. Emphasis is laid on glass-forming ability, mechanical properties, corrosion resistance, and biocompatibility.

show abstract

Section: Biocompatibility Of Ti-based Bmgsmentioning

confidence: 99%

Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Gong

Deng

Jin

et al. 2016

Metals

View full text Add to dashboard Cite

show abstract

“…[ 69 ] Further exploration of the composition space revealed Ca-rich alloys with signifi cantly increased casting diameters, and improved thermoplastic processing properties, excellent cell proliferation, and increased bone hyperplasia. [ 72,75,76 ] While the Young's modulus of the ternary systems is almost identical to that of dense cortical bone (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), the strengths are not as impressive as the Mg-rich systems, exhibiting failure in compression at around 400 MPa. Despite very limited H 2 evolution, the corrosion of the ternary alloys is very rapid, with some of the Ca-rich alloy pins dissolving completely within just 3 h. [ 75 ] Recently however, it has been demonstrated that additional alloying elements such a Yb and Sr can signifi cantly reduce the corrosion rate of the Ca-rich systems (Figure 4 ), bringing it signifi cantly below crystalline Mg-alloys, and suggesting a viable alternative to the smallerdiameter Mg-rich systems.…”

Section: Glassy Magnesium Alloysmentioning

confidence: 95%

“…[ 18 ] Cu-free alloys were produced by Oak and Inoue in the Ti-Pd-Zr-Si system -with good corrosion resistance, high hardness and strength, and good ductility, although the samples were in ribbon form only due to poor GFA. [ 19 ] More recently, alloys designed based on individual elemental toxicity, were produced in fully glassy form by Calin et al, [ 20 ] in the TiNbZrSi system, although again only in ribbon form -bulk samples were not possible due to the low GFA -but the corrosion behavior was again superior to Ti-6Al-4V. Xie et al reported that spark sintering of gas-atomized Ti-MG powders can produce high-density, large-volume parts [ 21 ] with good corrosion resistance (although no comparisons were made to as-cast BMGs or commercial alloys).…”

Section: Ti Systemsmentioning

confidence: 99%

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

et al. 2016

View full text Add to dashboard Cite

Their inherent lack of dislocations and hence slip planes leads to exceptionally high strength and elasticity, approaching the theoretical limit. While oxide glasses and ceramics exhibit low toughness and brittle failure, BMGs can display toughness comparable to crystalline metals. [ 2 ] The lack of grain structure means that BMGs are homogeneous and exhibit isotropic behavior, even at sub-micrometer length scales, and, without grain boundaries or precipitates as oxidation sites, corrosion rates are significantly reduced compared to conventional metals.BMGs soften above an alloy-specifi c glass-transition temperature ( T g ) before eventual, time-dependent, crystallization at a higher, crystallization temperature ( T x ). In this supercooled liquid region (SCLR) between T g and T x , the viscous BMGs may be plastically shaped under low applied forces using polymer-processing techniques, such as hot embossing, extrusion, foaming, and injection and blow moulding, before again cooling to a solid metallic glass. With relatively low processing temperatures and no solidifi cation shrinkage, parts can be formed to netshape with excellent accuracy, and geometries, and surface patterns previously diffi cult in metals can be achieved with ease. [3][4][5][6][7] Such remarkable properties and behavior have led to significant interest in BMGs as engineering materials over the past 20 years, but it is only recently that their potential for use as a biomaterial has been studied. [ 8 ] To date, our understanding of material biocompatiblity has evolved mainly through empirical testing, observing the interaction of materials with cells and host tissue in vitro and in vivo. Materials can induce host responses varying from local and systemic infl ammation, hypersensistivity, toxicity, and even tumorogenesis, meaning that thorough evidence of material safety is required before regulatory approval and clinical translation. We now largely recognise the material characteristics that generate both favorable and undesired host responses, as outlined by Williams, [ 9 ] offering the opportunity for informed material design, while being cognisant that biocompatibility is specifi c to the application and host environment. [ 10 ] The original requirement of fi rst generation "biocompatible" materials was bio-inertness. [ 11 ] This included a resistance to corrosion in the body, and here Ti-and Co-based alloys scored highly. [ 12 ] Less-inert metals, such as Mg, were therefore not deemed suitable, although the ions released on dissolution are generally not harmful to the human body. However, current design requirements for biomaterials, including most recently biometals, include eliciting an appropriate host response, [ 13 ] and this can include the need to biodegrade and resorb. There are potential advantages for BMGs that span applications of With increasing knowledge of the materials science of bulk metallic glasses (BMGs) and improvements in their properties and processing, they have started to become candidate materials for biomedical dev...

show abstract

“…higher strength, and in part, a lower Young's modulus, as well as higher wear resistance, and comparable corrosion stability. [4,5], with the aim to be used for implant applications. Both alloys showed very low corrosion rates in simulated body fluid and apatite forming ability [6].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…Both alloys showed very low corrosion rates in simulated body fluid and apatite forming ability [6]. In addition, the Nb containing alloy showed an improved glass-forming ability and mechanical properties compared to the Ti 75 Zr 10 Si 15 [4][5][6].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Self-organized double-wall oxide nanotube layers on glass-forming Ti-Zr-Si(-Nb) alloys

Sopha

Pohl

Damm

et al. 2017

Materials Science and Engineering: C

Self Cite

View full text Add to dashboard Cite

In this work, we report for the first time on the use of melt spun glass-forming alloysTi 75 Zr 10 Si 15 (TZS) and Ti 60 Zr 10 Si 15 Nb 15 (TZSN) -as substrates for the growth of anodic oxide nanotube layers. Upon their anodization in ethylene glycol based electrolytes, highly ordered nanotube layers were achieved. In comparison to TiO 2 nanotube layers grown on Ti foils, under the same conditions for reference, smaller diameter nanotubes (~116 nm for TZS and ~90 nm for TZSN) and shorter nanotubes (~11.5 µm and ~6.5 µm for TZS and TZSN, respectively) were obtained for both amorphous alloys. Furthermore, TEM and STEM studies, coupled with EDX analysis, revealed a double-wall structure of the as-grown amorphous oxide nanotubes with Ti species being enriched in the inner wall, and Si species in the outer wall, whereby Zr and Nb species were homogeneously distributed.

show abstract

Designing biocompatible Ti-based metallic glasses for implant applications

Cited by 193 publications

References 58 publications

Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Review on the Research and Development of Ti-Based Bulk Metallic Glasses

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

Self-organized double-wall oxide nanotube layers on glass-forming Ti-Zr-Si(-Nb) alloys

Contact Info

Product

Resources

About