Designer benzodiazepines: A new challenge

Moosmann, Bjoern; King, Leslie A.; Auwärter, Volker

doi:10.1002/wps.20236

Cited by 86 publications

(70 citation statements)

References 6 publications

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“…Flubromazepam (26) is the second of the class to be put on the market and was a drug candidate described first in 1962 by Sternbach et al Its potency is said to be possibly higher than those of bromazepam, diazepam and nitrazepam [102,103].…”

Section: Benzodiazepines: Flubromazepammentioning

confidence: 99%

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An overview of emerging and new psychoactive substances in the United Kingdom

Beharry

Gibbons

2016

Forensic Science International

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The purpose of this review is to identify emerging or new psychoactive substances (NPS) by undertaking an online survey of the UK NPS market and to gather any data from online drug fora and published literature. Drugs from four main classes of NPS were identified: psychostimulants, dissociative anaesthetics, hallucinogens (phenylalkylamine-based and lysergamide-based materials) and finally benzodiazepines. For inclusion in the review the 'user reviews' on drugs fora were selected based on whether or not the particular NPS of interest was used alone or in combination. NPS that were use alone were considered. Each of the classes contained drugs that are modelled on existing illegal materials and are now covered by the UK New Psychoactive Substances Bill in 2016. AbstractThe purpose of this review is to identify emerging or new psychoactive substances (NPS) by undertaking an online survey of the UK NPS market and to gather any data from online drug fora and published literature. Drugs from four main classes of NPS were identified: psychostimulants, dissociative anaesthetics, hallucinogens (phenylalkylamine-based and lysergamide-based materials) and finally benzodiazepines. For inclusion in the review, the 'user reviewers' on drugs fora were selected based on whether or not the particular NPS of interest was used alone or in combination. NPS that were used alone were considered.Each of the classes contained drugs that are modelled on existing illegal materials and will be covered by the UK New Psychoactive Substances Bill in 2016.

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Section: Benzodiazepines: Flubromazepammentioning

confidence: 99%

“…Benzodiazepines are also used in the clinical setting to treat cases of acute toxicity related to NPS use [102].…”

Section: Benzodiazepines-flubromazepammentioning

confidence: 99%

An overview of emerging and new psychoactive substances in the United Kingdom

Beharry

Gibbons

2016

Forensic Science International

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“…Some of these drugs have been found in NPS. Phenazepam, for example, is one of several designer benzodiazepines available online (Moosmann et al, 2015).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The potential utility of some legal highs in CNS disorders

Davidson

Schifano

2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Heterocyclic compounds comprising a 1,4-benzodiazepine (BDZ) ring have been a topic of continued interest as they exhibit a wide spectrum of drug-like profiles such as good anticonvulsant activity against acutely elicited seizure, particularly for the central nervous system [1–5]. Many biologically active small molecules with such a core structure have been marketed for the treatment of various diseases, mostly as psychotropic substances [6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of new tricyclic 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepine derivatives by [3⁺ + 2]-cycloaddition/rearrangement reactions

Luan

Song

et al. 2018

Beilstein J. Org. Chem.

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Two new series of tricyclic heterocycles, namely 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepinium salts 10 and the related neutral, free bases 13 were synthesized from 4-acetoxy-1-acetyl-4-phenylazo-1,2,3,4-tetrahydroquinolines 8 and nitriles 9 in the presence of aluminium chloride by the [3+ + 2]-cycloaddition reaction of the in situ generated azocarbenium intermediates 14 followed by a ring-expansion rearrangement. In the rearrangement reaction, the phenyl substituent in the initially formed spiro-triazolium adducts 16 underwent a [1,2]-migration from C(3) to the electron-deficient N(2). This led to the ring expansion from 6-membered piperidine to 7-membered diazepine furnishing the tricyclic 1,2,4-triazole-fused 1,4-benzodiazepines.

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Designer benzodiazepines: A new challenge

Cited by 86 publications

References 6 publications

An overview of emerging and new psychoactive substances in the United Kingdom

An overview of emerging and new psychoactive substances in the United Kingdom

The potential utility of some legal highs in CNS disorders

Synthesis of new tricyclic 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepine derivatives by [3⁺ + 2]-cycloaddition/rearrangement reactions

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Designer benzodiazepines: A new challenge

Cited by 86 publications

References 6 publications

An overview of emerging and new psychoactive substances in the United Kingdom

An overview of emerging and new psychoactive substances in the United Kingdom

The potential utility of some legal highs in CNS disorders

Synthesis of new tricyclic 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepine derivatives by [3+ + 2]-cycloaddition/rearrangement reactions

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Synthesis of new tricyclic 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepine derivatives by [3⁺ + 2]-cycloaddition/rearrangement reactions