Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies

Pakela, Julia M.; Hedrick, Taylor L.; Lee, Seung Yup; Vishwanath, Karthik; Zanfardino, Sara; Chung, Yooree G.; Helton, Michael; Kolodziejski, Noah J.; Stapels, Christopher J.; McAdams, Daniel R.; Fernandez, Daniel E.; Christian, James F.; Feinberg, Stephen E.; Mycek, Mary Ann

doi:10.1117/12.2252811

Cited by 3 publications

(3 citation statements)

References 13 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Raw photon counts and autocorrelation plots were calculated via multitau methods and displayed in real time for four DCS channels along with a reflectance spectrum. Before this in vivo study, the basic performance of the entire system (device + optical probes + GUI) was verified on tissue-simulating phantoms 30 , 31 …”

Section: Methodsmentioning

confidence: 99%

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

et al. 2017

Self Cite

View full text Add to dashboard Cite

In reconstructive surgery, the ability to detect blood flow interruptions to grafted tissue represents a critical step in preventing postsurgical complications. We have developed and pilot tested a compact, fiber-based device that combines two complimentary modalities-diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy-to quantitatively monitor blood perfusion. We present a proof-of-concept study on an in vivo porcine model (n=8). With a controllable arterial blood flow supply, occlusion studies (n=4) were performed on surgically isolated free flaps while the device simultaneously monitored blood flow through the supplying artery as well as flap perfusion from three orientations: the distal side of the flap and two transdermal channels. Further studies featuring long-term monitoring, arterial failure simulations, and venous failure simulations were performed on flaps that had undergone an anastomosis procedure (n=4). Additionally, benchtop verification of the DCS system was performed on liquid flow phantoms. Data revealed relationships between diffuse optical measures and state of occlusion as well as the ability to detect arterial and venous compromise. The compact construction of the device, along with its noninvasive and quantitative nature, would make this technology suitable for clinical translation.

show abstract

Section: Methodsmentioning

confidence: 99%

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Technical details on algorithm implementation are described in [9], and phantom verification of the method is found in [14]…”

Section: Methodsmentioning

confidence: 99%

Novel diffuse optics system for continuous tissue viability monitoring: extended recovery in vivo testing in a porcine flap model

Lee

Pakela

Hedrick

et al. 2017

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV

Self Cite

View full text Add to dashboard Cite

In reconstructive surgery, tissue perfusion/vessel patency is critical to the success of microvascular free tissue flaps. Early detection of flap failure secondary to compromise of vascular perfusion would significantly increase the chances of flap salvage. We have developed a compact, clinically-compatible monitoring system to enable automated, minimally-invasive, continuous, and quantitative assessment of flap viability/perfusion. We tested the system’s continuous monitoring capability during extended non-recovery surgery using an in vivo porcine free flap model. Initial results indicated that the system could assess flap viability/perfusion in a quantitative and continuous manner. With proven performance, the compact form constructed with cost-effective components would make this system suitable for clinical translation

show abstract

“…To estimate total hemoglobin concentration and tissue oxygen saturation, we employed a Monte Carlo lookup table (MCLUT)-based inverse method to fit the measured reflectance spectra 7,15 . Technical details on algorithm implementation are described in [Ref 5 and 16] and phantom verification of the method is found in [Ref 17]. …”

Section: Methodsmentioning

confidence: 99%

In vivo preclinical verification of a multimodal diffuse reflectance and correlation spectroscopy system for sensing tissue perfusion

Pakela

Lee

Hedrick

et al. 2017

Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics

Self Cite

View full text Add to dashboard Cite

In reconstructive surgery, impeded blood flow in microvascular free flaps due to a compromise in arterial or venous patency secondary to blood clots or vessel spasms can rapidly result in flap failures. Thus, the ability to detect changes in microvascular free flaps is critical. In this paper, we report progress on in vivo pre-clinical testing of a compact, multimodal, fiber-based diffuse correlation and reflectance spectroscopy system designed to quantitatively monitor tissue perfusion in a porcine model’s surgically-grafted free flap. We also describe the device’s sensitivity to incremental blood flow changes and discuss the prospects for continuous perfusion monitoring in future clinical translational studies.

show abstract

Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies

Cited by 3 publications

References 13 publications

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

Novel diffuse optics system for continuous tissue viability monitoring: extended recovery in vivo testing in a porcine flap model

In vivo preclinical verification of a multimodal diffuse reflectance and correlation spectroscopy system for sensing tissue perfusion

Contact Info

Product

Resources

About