Design, synthesis, spectroscopic characterizations, antidiabetic, in silico and kinetic evaluation of novel curcumin-fused aldohexoses

Ezati, Mohammad; Ghavamipour, Fahimeh; Adibi, Hadi; Pouraghajan, Khadijeh; Arab, Seyed Shahriar; Sajedi, Reza H.; Khodarahmi, Reza

doi:10.1016/j.saa.2022.121806

Cited by 15 publications

(5 citation statements)

References 48 publications

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“…Pancreatic enzyme activity did not show a significant difference after oral digestive enzyme administration, according to Ritz et al (1995a , 1995b ) and Ezati et al (2023) , who speculated that distinctions in the physical structure of intrinsic animal enzymes versus those of bacterial or plant sources could prevent inhibitory effects of pancreatic enzymatic activity. However, when chicks were fed a diet supplemented with exogenous amylase and protease, Mahagna et al (1995) discovered reduced intestinal protease activity.…”

Section: Discussionmentioning

confidence: 99%

Growth performance of broiler chickens fed diets supplemented with amylase and protease enzymes individually or combined

Radhi,

Arif,

Rehman

et al. 2023

Open Vet J

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Background: Feed additives that increase nutrient availability in feeds have gained a lot of interest. Aim: An experiment was conducted to determine whether amylase, protease and their combined supplementation affected broiler performance. Methods: Two hundred eighty (280) broiler chicks were selected and distributed randomly into 28 replicate pens with four treatment groups and seven replicates under Completely Randomized Design (CRD). A total of four diets were developed, having 0, 100g, 100g and 100+100g of control (AP0), amylase (A1), protease (P1) and amylase + protease (AP1)/ton of feed, respectively. Four replicates of each treatment were fed each diet. Each diet was randomly allotted to each group. Ad-libitum feeding was provided to the birds. The feeding program had starter and finisher diets. Upon completion of the experiment, three birds from each pen were slaughtered to analyze the carcass characteristics and organ weight. Results: Differences were insignificant between 100g/ton of amylase supplementation and FI, BWG, or FCR (P>0.05). Supplementation with 100g/ton of protease did not significantly affect FI, BWG, and FCR (P>0.05). Similarly, 100+100g/ton of amylase + protease addition had no significant effect on FI, BWG, and FCR (P>0.05). None of the treatments significantly affected carcass weight, abdominal fat percentage, dressing percentage, drumstick, wings, breast and thigh weights (P>0.05). In addition, there were no significant effects (P>0.05) on the weight of the heart, liver, gizzard, and spleen. Conclusion: In conclusion, amylase, protease, and their combined supplementation at a rate of 100g/ton of feed did not influence BWG, FI, FCR, carcass characteristics, or organ weight.

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Section: Discussionmentioning

confidence: 99%

Growth performance of broiler chickens fed diets supplemented with amylase and protease enzymes individually or combined

Radhi,

Arif,

Rehman

et al. 2023

Open Vet J

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“…This method was adopted with slight modification in reported method. 32 Rat intestinal acetone powder (1 g) was added to phosphate buffer (100 mL, pH 7.0, 0.1 M). The sonication of reaction mixture was carried out for 30 min, which was followed by centrifugation (10 000 rpm, 4 °C for 10 min.).…”

Section: Methodsmentioning

confidence: 99%

Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies

et al. 2023

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“…Curcumin is insoluble in water and easily efficient in organic solvents [ 495 ]; the active functional groups of curcumin can be oxidized by electron transfer and hydrogen abstraction [ 496 ], and curcumin is more durable in acidic to neutral conditions than in alkaline circumstances [ 495 , 496 , 497 ]. Curcumin, as an enzyme inhibitor, has proper structural characteristics including a flexible backbone, hydrophobic nature, and different available hydrogen bond (H-bond) donors and acceptors [ 498 ]. Curcumin is stable to heat but is light-sensitive and produces singlet oxygen and other reactive oxygen species (ROS) when exposed to the sun, which is also a photodynamic and photobiological property of curcumin [ 499 ].…”

Section: The Health Benefits Of Curcuminoids (Curcumin Demethoxycurcu...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Design, synthesis, spectroscopic characterizations, antidiabetic, in silico and kinetic evaluation of novel curcumin-fused aldohexoses

Cited by 15 publications

References 48 publications

Growth performance of broiler chickens fed diets supplemented with amylase and protease enzymes individually or combined

Growth performance of broiler chickens fed diets supplemented with amylase and protease enzymes individually or combined

Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

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