Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives

Abstract

This work reports the design and synthesis of a library of thieno[2,3-d]pyrimidine derivatives and screened for their in vitro anti-plasmodial and cytotoxic assessment to identify a lead compound in the development of potential antimalarials.

Effect of Nursing Model Based on Rosenthal Effect on Self-Efficacy and Cognition of Life Meaning in Patients with Non-Small-Cell Lung Cancer

“…After the treatment begins, the nurses divide the patients into a group mode, organize the NSCLC patients between the groups to share their disease and treatment feelings, and guide the patients themselves, their families, and members of the group to make positive evaluations, so as to help the patients gain a sense of emotional belonging and support. It can effectively enhance self-efficacy of patients and reduce their self-burden [ 17 ]. Nursing staff establish a good emotional outlet for NSCLC patients in the mode of group communication, help patients vent their negative emotions through expressions, and guide other patients to encourage other patients in a timely manner, so as to effectively relieve the anxiety and depression of NSCLC patients.…”

“…After the treatment begins, the nurses divide the patients into a group mode, organize the NSCLC patients between the groups to share their disease and treatment feelings, and guide the patients themselves, their families, and members of the group to make positive evaluations, so as to help the patients gain a sense of emotional belonging and support. It can effectively enhance self-efficacy of patients and reduce their self-burden [17].…”

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

“…Isosteric replacement of -NH with (-S-) has literature precedence in improving antiproliferative and microtubule depolymerizing activities [ 27 ]. Moreover, pharmacological applications of 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3- d ]pyrimidines have been extensively illustrated in various reports in the literature [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. In addition, the lead tricyclic compounds and the proposed target compounds incorporate a p-methoxyphenyl substitution akin to colchicine and CA-4 ( Figure 1 ).…”

Synthesis, in vitro and docking studies of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one derivatives as agents for the treatment of Alzheimer's disease

“…Some new thieno [2,3-d]pyrimidine-4(3H)-one derivatives showed good analgesic activity by using Eddy´s hot plate method [22]. There are data indicating that tetrahydrobenzo [4,5]thieno [2,3-d]pyrimidine scaffolds may serve as models for the development of antimalarial agents [23]. Some of the 5-alkoxytetrazolo [1,5-c]thieno[2,3-e]pyrimidine derivatives may exhibit anticonvulsant and antidepressant effects, which makes it possible to design compounds based on them with an effect on the central nervous system [24].…”