Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones

Bandgar, B. P.; Chavan, Hemant V.; Adsul, Laxman K.; Thakare, Vishnu N.; Shringare, Sadanand N.; Shaikh, Rafik U.; Gacche, Rajesh N.

doi:10.1016/j.bmcl.2012.10.031

Cited by 32 publications

(18 citation statements)

References 39 publications

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“…Bandgar et al .,[ 16 ] have synthesized a series of novel pyrazole integrated benzophenones from 1-methyl-5-(2, 4, 6-trimethoxy-phenyl)-1H-pyrazole. All the compounds were proved as marked anti-inflammatory potential against various inflammatory mediators.…”

Section: Synthetic Aspects Of Pyrazolementioning

confidence: 99%

Current status of pyrazole and its biological activities

et al. 2016

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Pyrazole are potent medicinal scaffolds and exhibit a full spectrum of biological activities. This review throws light on the detailed synthetic approaches which have been applied for the synthesis of pyrazole. This has been followed by an in depth analysis of the pyrazole with respect to their medical significance. This follow-up may help the medicinal chemists to generate new leads possessing pyrazole nucleus with high efficacy.

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Section: Synthetic Aspects Of Pyrazolementioning

confidence: 99%

Current status of pyrazole and its biological activities

et al. 2016

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“…These predictions encouraged us to synthesize hybrid compounds containing arylpyrazole combined with chalcone scaffold. Based on the earlier findings and in continuation of our interest in the synthesis of novel bioactive molecules with potential anti-inflammatory activities [38][39][40][41] , a new series of pyrazolyl chalcones (10a-n) have been synthesized and evaluated for their anti-inflammatory potential.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, characterization andin vitroandin vivoanti-inflammatory evaluation of novel pyrazole-based chalcones

Chavan

Adsul

Kotmale

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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A series of novel pyrazole-based chalcones have been designed, synthesized from 1-methyl-5-(2,4,6-trimethoxyphenyl)-1H-pyrazole (6). The structures of regioisomers 6 and 7 were determined by 2D The newly synthesized compounds were tested for their inhibitory activity against COX-1 and COX-2 using an in vitro cyclooxygenase (COX) inhibition assay. Moreover, they were investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw edema model for acute inflammation and cotton pellet-induced granuloma model for chronic inflammation. All the synthesized compounds showed potential to demonstrate anti-inflammatory activities, of particular interest compounds 10i, 10e, 10f, and 10h were found to be potent anti-inflammatory agents.

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“…celecoxib, ENMD-2076, R1530, PNU-32945, rimonabant, metamizole, and sulfaphenazole). [13][14][15][16] Cyanopyridine and pyrazoles are also valuable intermediates in organic synthesis. 17,18 In recent years, many synthetic approaches for preparation of 2-aminopyridine-3-carbonitriles and pyranopyrazoles have been developed; each has its advantages and disadvantages, namely longer reaction time, toxic solvents, harsh reaction conditions and low yields.…”

Section: Introduction *mentioning

confidence: 99%

A concise route for the one-pot multi-component synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles and pyranopyrazoles using cobalt (II) nitrate hexahydrate as catalyst

PEJMAN¹,

Hazeri²,

Fatahpour³

et al. 2019

Rev.Roum.Chim.

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Three facile and efficient routes for one-pot, cobalt (II) nitrate hexahydrate catalyzed multi-component synthesis of 2-amino-3cyanopyridine and pyranopyrazole derivatives have been developed. The present protocols offer the products in good yields from the simple and readily available starting materials. The other salient features of these protocols are operational simplicity, easy isolation of product without the need of column chromatographic purification, and the use of cobalt (II) nitrate hexahydrate as an efficient catalyst.

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Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones

Cited by 32 publications

References 39 publications

Current status of pyrazole and its biological activities

Current status of pyrazole and its biological activities

Design, synthesis, characterization andin vitroandin vivoanti-inflammatory evaluation of novel pyrazole-based chalcones

A concise route for the one-pot multi-component synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles and pyranopyrazoles using cobalt (II) nitrate hexahydrate as catalyst

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