Design, Synthesis, and Activities of Novel Derivatives of Isophthalamide and Benzene-1, 3-disulfonamide

Liu, X; Wang, S; Zhang, J; Zhang, F; Li, G; Wang, B; Shao, Ying; Zhang, L; Fang, Long; Cheng, Maosheng

doi:10.1016/s1005-9040(06)60115-3

Cited by 10 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, a direct electron transfer of hemoglobin at the dendrimer-MWNTs-Au nanoparticles composite film modified glassy carbon electrode was studied. The sensor with dendrimer-MWNTs-Au nanoparticles composite film gave an excellent electrocatalytic response to the reduction of hydrogen [19]. Zhang et al reported also a novel kind of composite multi-walled carbon nanotube/sol-gel imprinted electrochemical sensor for the determination of resveratrol [7].…”

Section: Nanomaterials Composite Modified Electrodementioning

confidence: 99%

Research Advance of Electrochemical Sensor Fabricated with Nanomaterials and their Application

Gao

Qian

Liu

et al. 2011

AMR

View full text Add to dashboard Cite

Nanomaterials include nanometal, nanooxide, carbon nanotube, carbon nanotube composite and other types of nanomaterials. They provide a significant way for the manufacture of sensors due to their small size, larger specific surface area, surface atomic slots insufficiency and more active sites. The rapid development of electrochemical sensor fabricated with nanomaterials is of significant value. In this article, we address some of the main advances in this field over the past few years, discussing the research progress of electrochemical sensor fabricated with nanomaterials and their application.

show abstract

Section: Nanomaterials Composite Modified Electrodementioning

confidence: 99%

Research Advance of Electrochemical Sensor Fabricated with Nanomaterials and their Application

Gao

Qian

Liu

et al. 2011

AMR

View full text Add to dashboard Cite

show abstract

“…In our previous study, a series of 4‐methoxyisophthalamides (Figure c) were designed and synthesized by replacing the two 3‐(aminomethyl)pyridine groups with two substituted phenyl groups. Among them, nearly 20% of compounds showed stronger inhibitory activities than picotamide on platelet aggregation . According to the results of the analysis of pharmacological activities, steric quantitative structure–activity relationships were established.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and biological evaluation of 4‐methoxy‐3‐arylamido‐N‐(substitutedphenyl)benzamide derivatives as potential antiplatelet agents

Liu

Chen

Qiu

et al. 2019

Archiv der Pharmazie

View full text Add to dashboard Cite

A series of 4-methoxy-3-arylamido-N-(substitutedphenyl)benzamides 6a-u were designed according to the splicing principle of structural design in the medicinal chemistry theory and were synthesized in five steps: nitration, acylation, ammoniation, reduction, and secondary ammoniation. The structures of the target compounds were characterized and verified by infrared, 1 H nuclear magnetic resonance (NMR), 13 C NMR, and electron spray ionization spectroscopy. Their in vitro antiplatelet aggregation activities induced by adenosine diphosphate (ADP) or arachidonic acid (AA) were assessed by Born's method. The biological evaluation revealed that all compounds exhibited certain levels of activities in both of the antiplatelet aggregation assays; compounds 6c (IC 50 = 3.84 μM) and 6f (IC 50 = 3.12 μM) displayed the strongest antiplatelet aggregation activities in the ADP-induced and AA-induced assay, separately. Moreover, compounds that had stronger activities were chosen for cell toxicity testing via the cell counting kit-8 assay. The results indicated that none of the compounds had obvious cell toxicity against L929 cells at the doses of 10 and 20 μM. It is worth pointing out that compound 6c showed the highest antiplatelet activity and the lowest cell toxicity. In general, 4-methoxy-3-arylamido-N-(substitutedphenyl)benzamides have the potential to become a kind of safer and more effective antiplatelet agents.

show abstract

Synthesis andin vitroanti-platelet aggregation activities of 2-methoxy-5-arylamido-N-(pyridin-3-yl-methyl)benzamides

Wang

Wang²,

Chen

et al. 2018

Arch. Pharm. Chem. Life Sci.

View full text Add to dashboard Cite

In order to discover novel compounds with anti-platelet aggregation activities, a series of novel 2-methoxy-5-arylamido-N-(pyridin-3-ylmethyl)benzamides (1a-n) were synthesized and their anti-platelet aggregation activities were evaluated by the turbidimetric method in response to the following agonists: adenosine diphosphate (ADP) (5 mM/L), arachidonic acid (AA) (20 µM/L), and collagen (1 mg/mL). Those synthesized compounds that have better in vitro activities were subjected to cell toxicity tests via cell counting kit-8 (CCK-8) assay. The biological evaluation revealed that compound 1a (IC 50 : 0.21 µM/L) exhibited the highest anti-platelet aggregation activities when ADP was selected as an inducer, and compound 1b (IC 50 : 0.23 µM/L) showed the best activities when AA was selected as inducer, and compound 1m (inhibition rate: 55.06%) had significant anti-platelet aggregation activities when collagen was selected as inducer among all target compounds. Moreover, the effect of cell toxicity exhibited that none of the compounds had obvious cell toxicity against L929 cells. Therefore, 2-methoxy-5-arylamido-N-(pyridin-3-ylmethyl)benzamides have the potential to become a novel kind of anti-platelet drugs and deserve further study. K E Y W O R D S2-methoxy-5-arylamido-N-(pyridin-3-yl-methyl)benzamides, anti-platelet aggregation, cell toxicity, picotamide, synthesis

show abstract

Design, Synthesis, and Activities of Novel Derivatives of Isophthalamide and Benzene-1, 3-disulfonamide

Cited by 10 publications

References 3 publications

Research Advance of Electrochemical Sensor Fabricated with Nanomaterials and their Application

Research Advance of Electrochemical Sensor Fabricated with Nanomaterials and their Application

Design, synthesis, and biological evaluation of 4‐methoxy‐3‐arylamido‐N‐(substitutedphenyl)benzamide derivatives as potential antiplatelet agents

Synthesis andin vitroanti-platelet aggregation activities of 2-methoxy-5-arylamido-N-(pyridin-3-yl-methyl)benzamides

Contact Info

Product

Resources

About