Design strategy for biodegradable Fe-based alloys for medical applications☆

Schinhammer, Michael; Hänzi, Anja C.; Löffler, Jörg F.; Uggowitzer, Peter J.

doi:10.1016/j.actbio.2009.07.039

Cited by 452 publications

(279 citation statements)

References 28 publications

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“…Furthermore, owing to including a high concentration of CO 2 gas in blood causing to create a uniform, compact and dense manganese carbonate crystals the degradation rate of Fe in vivo is slower than in vitro [50] and in most of the cases is longer than clinical needs [51]. Additionally, because of the low rate of blood circulation near the implants, utilization of Fe and its alloys for bone reconstruction purposes would be definitely lower than their corrosion rate.…”

Section: Disadvantages Of Fe and Its Alloysmentioning

confidence: 99%

“…Adding some alloying elements to pure Fe has been reported to be one of the most effective methods to accelerate the degradation rate of Fe to an acceptable level for practical clinical usage [12,44]. Among all of the Fe-based alloys, Fe-Mn alloys have been proved to be the most promising ones in accelerating the corrosion rate of Fe with similar mechanical properties (i.e., Young's modulus and ultimate tensile strength) to 316L SS [51]. Moreover, Mn can play an important role in promoting the growth of new bone and connective tissues as well as reducing bone loss [52,53] which could increase its bioactivity in orthopedic and dental applications.…”

Section: Disadvantages Of Fe and Its Alloysmentioning

confidence: 99%

See 1 more Smart Citation

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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Section: Disadvantages Of Fe and Its Alloysmentioning

confidence: 99%

Section: Disadvantages Of Fe and Its Alloysmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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“…Both pure Fe and pure Mg have been reported to possess excellent biocompatibility in the human body and show no signs of local or systemic toxicity [45,48,49].…”

Section: Outlinementioning

confidence: 99%

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

Peter¹,

Matekovits²,

Rosso³

2018

Biomaterials in Regenerative Medicine

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In all cases, when a material has to be used in medical applications, the knowledge of its physical, chemical and biological properties is of fundamental signiicance, since the direct contact between the biological system and the considered device could generate reactions whose long-term efects must be clearly quantiied. The class of materials that exhibits characteristics that allow their use for the considered applications are commonly called biomaterials. Patients sufering from diferent diseases generate a great demand for real therapies, where the use of biomaterials are mandatory. Commonly, metallic biomaterials are used because their structural functions; the high strength and resistance to fracture they can ofer, provide reliable performance primarily in the ields of orthopedics and dentistry.In metals, because of their particular structure, plastic deformation takes place easier, inducing good formability in manufacturing. The present paper is not encyclopaedic, but reports in the irst part some current literature data and perspectives about the possibility of use diferent class of metallic materials for medical applications, while the second part recalls some results of the current research in this ield carried out by the authors.

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“…Since most biodegradable iron stent remained intact after 1 year, intense work has been done on the developing novel Fe-based alloys aiming at both an increase in degradation rate and an improvement in the mechanical properties [69]. The novel Fe-based alloys (Fe-Mn [70], Fe-Mn-Pd [71]) indicate the feasibility of achieving Fe-based BDS with enhanced degradation rate and suitable strength and ductility. Nevertheless, the long-term safety of Fe-based stents and the degradation behavior in vivo are still to be evaluated.…”

Section: Biodegradable Stentsmentioning

confidence: 99%

Current status of research and application in vascular stents

Yang

Maitz

2013

Chin. Sci. Bull.

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Cardiovascular diseases have been the leading cause of death in modern society. Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions. During the twenty-five years' development of vascular stents, revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged. In this review, the evolution of vascular stents is summarized, aiming to provide a glimpse into the future of vascular stents. Advanced designs, focusing on the investigations of new substrates, new platforms, new drugs and new biomolecules are currently under evaluation with promising clinical studies. The concept of "time sequence functional stent" has been raised in this paper. It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization. It also shows long-term inertness without release of toxic ions or toxic degradation products. The success of this concept is briefly presented with a clinical study in this model stents.

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Design strategy for biodegradable Fe-based alloys for medical applications☆

Cited by 452 publications

References 28 publications

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

Current status of research and application in vascular stents

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