Design options for mRNA-encoded BoNT Antitoxins employing camelid single-domain antibody (VHH) components

Shoemaker, Charles B.; Lam, Kwok Ho; Thran, Moritz; Schlake, Thomas; Vazquez-Cintron, Edwin; McNutt, Patrick; Jin, Rongsheng

doi:10.1016/j.toxicon.2018.11.251

Cited by 2 publications

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“…The results provided mAbs that could prove useful for toxin intracellular activity reversal and relief of paralysis as well as identifying epitopes that could be targeted by small molecule inhibitors. Liposomal "delivery vehicles" could be used to ensure the delivery of antibodies into motoneurons and reverse paralysis [67,86].…”

Section: Enhance Adherence and Targeting Efficiencymentioning

confidence: 99%

Antibodies and vaccines against botulinum toxins: Available measures and novel approaches

Rasetti-Escargueil

Lemichez

Popoff

2021

Toxicon

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Enhance Adherence and Targeting Efficiencymentioning

confidence: 99%

Antibodies and vaccines against botulinum toxins: Available measures and novel approaches

Rasetti-Escargueil

Lemichez

Popoff

2021

Toxicon

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Antibodies and Vaccines against Botulinum Toxins: Available Measures and Novel Approaches

Rasetti-Escargueil

Popoff

2019

Toxins

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Botulinum neurotoxin (BoNT) is produced by the anaerobic, Gram-positive bacterium Clostridium botulinum. As one of the most poisonous toxins known and a potential bioterrosism agent, BoNT is characterized by a complex mode of action comprising: internalization, translocation and proteolytic cleavage of a substrate, which inhibits synaptic exocytotic transmitter release at neuro-muscular nerve endings leading to peripheral neuroparalysis of the skeletal and autonomic nervous systems. There are seven major serologically distinct toxinotypes (A–G) of BoNT which act on different substrates. Human botulism is generally caused by BoNT/A, B and E. Due to its extreme lethality and potential use as biological weapon, botulism remains a global public health concern. Vaccination against BoNT, although an effective strategy, remains undesirable due to the growing expectation around therapeutic use of BoNTs in various pathological conditions. This review focuses on the current approaches for botulism control by immunotherapy, highlighting the future challenges while the molecular underpinnings among subtypes variants and BoNT sequences found in non-clostridial species remain to be elucidated.

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Design options for mRNA-encoded BoNT Antitoxins employing camelid single-domain antibody (VHH) components

Cited by 2 publications

References 0 publications

Antibodies and vaccines against botulinum toxins: Available measures and novel approaches

Antibodies and vaccines against botulinum toxins: Available measures and novel approaches

Antibodies and Vaccines against Botulinum Toxins: Available Measures and Novel Approaches

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