Design optimization of an air atmospheric pressure plasma‐jet device intended for medical use

Abstract

The current and potential applications of atmospheric pressure plasmas in medicine generate an increasing need to develop safe and reliable plasma devices for patient treatment. This paper shows how the estimation of safety risks, the stability of the generated plasma, and the effectiveness in the aimed application can orientate the design process of a specific atmospheric pressure plasma device intended for clinical use. A promising plasma jet device operated with air is optimized, leading to a configuration with a more advanced design that reduces the temperature of the effluent, prevents the material degradation and improves the isolation of the high voltage components. The effects of the plasma jet treatment are investigated by chemical analysis of demineralized water and inactivation tests on E. coli cultures.

Direct Treatment of Liquids Using Low-Current Arc in Ambient Air for Biomedical Applications

“…The observed concentrations were two orders of magnitude higher than those of 5 mL DI water treated for 1 min with commercially available NEAPPJ operated with He (0.37 mg/L of H2O2, 0.18 mg/L of NO2 − , and 0.06 mg/L of NO3 − ). Additionally, considerably small concentrations of RONS in water treated using NEAPPJ (up to 890 µg/L of H2O2, up to 180 µg/L of NO2 − , and up to 410 µg/L of NO3 − ) [20][21][22]45,46] and custom plasma jets operated with air or addition of air (up to 9.3 mg/L of H2O2, up to 4 mg/L of NO2 − , and up to 5.5 mg/L of NO3 − ) [14,28,47,48] were reported elsewhere, confirming the high efficiency of the developed AALCA as compared with commonly used nonequilibrium plasma jets.…”

“…The temperature of the water increased from about 25 • C to about 30 • C during the treatment (similar results were confirmed by measurements using a thermocouple). The use of flow allows for a temperature of the produced PTW below 37 • C, which is safe for the human body and could be used in medical applications [47,60]. Additionally, the difference in the flow rate allowed for compensation of the evaporation of the liquid and retention of the same level of liquid inside the dish, ensuring the same discharge gap and parameters of the plasma during treatment.…”

Prevention of biofilm re‐development on Ti‐6Al‐4V alloy by cometary discharge with a metallic grid

“…Here, it should be mentioned that there have been many works (e.g. refs ) dedicated to microorganism inactivation in cavities, capillaries, or other tubes where also the biofilm may develop. However, the mentioned works deal with the inactivation of planctonic forms of microorganisms; a systematic study of biofilm inactivation by a plasma is still missing.…”

Application of plasma jet to the inhibition of the proliferation of hepatic malignant cells via reactive oxygen species generation

“…The emission current of the investigated plasma jet was first measured to assess whether the DBD plasma jet is applicable to the in vivo treatment. The intensity of the emission current should be limited to avoid electrical shock . The measured emission current was also used to estimate the charge density (electron density) of the plasma bullets.…”

“…The intensity of the emission current should be limited to avoid electrical shock. [34,35] The measured emission current was also used to estimate the charge density (electron density) of the plasma bullets. The physical parameters such as electron density and electron temperature are critical factors determining the jetʼs performance.…”