Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer’s disease

Sun, Dongdong; Li, Nuan; Zhang, Weiwei; Zhao, Zhiwei; Mou, Zhipeng; Huang, Donghui; Liu, Jie; Wang, Weiyun

doi:10.1016/j.colsurfb.2016.08.052

Cited by 149 publications

(62 citation statements)

References 64 publications

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“…3 PLGA nanoparticles can be modi-ed, for example with contrast agents and drugs, by either covalent coupling or non-covalent loading using the hydrophobic effect. [4][5][6] PLGA protects the drug from fast degradation and the release time of the encapsulated cargo from the particles can be modulated by altering the synthesis parameters and polymer composition. 7 Loading the particles with liquid peruorocarbons (PFCs) for uorine ( 19 F) MRI is advantageous for biomedical use, as it can be used for in vivo non-invasive imaging.…”

Section: Introductionmentioning

confidence: 99%

Design of triphasic poly(lactic-co-glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Design of triphasic poly(lactic-co-glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications

et al. 2018

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“…Moreover, systemic toxicity of PLGA@QT NPs (20 mg/kg, i.v.) was not observed in the histological study of mouse tissues 5, 15, or 30 days after injection (Sun et al., ).…”

Section: Quercetin and Memorymentioning

confidence: 91%

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei

Mirzababaei

Nassiri‐Asl

2018

Journal of Food Science

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Quercetin (3,3',4',5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the research on quercetin and its role in memory in both animals and humans. Articles were chosen from the Scopus, PubMed, and Web of Science databases. In this review, we describe and summarize the importance of quercetin's presence in the body, particularly in the brain; its kinetics, including its absorption, metabolism, distribution, and excretion; its behavioral effects; and some of the possible mechanisms of action of quercetin on memory in different animal models. Several important pathways that may be involved in the processes of learning and memory, long-term potentiation, and cognition may be impaired during neurological diseases or other medical conditions. As dietary quercetin is important, provision of its best formulation for delivery to the brain as a nutraceutical and in clinical translational research for the prevention or treatment of Alzheimer's disease and other types of dementia is necessary.

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“…However, an important aspect to consider, besides proving a therapeutic concept in animal models and generating a drug to effectively translate that concept to clinics, is the challenge to efficaciously deliver a molecule to the brain due to constraints of bioavailability and the blood-brain barrier. In that regard, nanoparticle-based drug engineering (234) and/or MSC-based therapy (200), if proved efficient, could help overcome a rampant problem encountered in the pharmaceutical industry in general and lead to clinical trials with more positive outcomes. Hence, XBP1 and downstream pathways (see Figure 1) merit aggressive and thorough exploration as genuine therapeutic targets that could pave the way for more effective disease-modifying therapies in AD pathology.…”

Section: Resultsmentioning

confidence: 99%

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

Cissé

Duplan

Checler

2016

Mol Med

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X-box binding protein 1 (XBP1) is a unique basic region leucine zipper transcription factor that was isolated two decades ago in a search for regulators of major histocompatibility complex class II gene expression. XBP1 is a very complex protein that regulates many physiological functions, including the immune system, inflammatory responses and lipid metabolism. Evidence over the past few years suggests that XBP1 also plays an important role in pathological settings, since its activity as a transcription factor has profound effects on the prognosis and progression of diseases such as cancer, neurodegeneration and diabetes. Here we provide an overview of recent advances in our understanding of this multifaceted molecule, particularly in regulating synaptic plasticity and memory function, and the implications in neurodegenerative diseases, with an emphasis on Alzheimer's disease.

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Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer’s disease

Cited by 149 publications

References 64 publications

Design of triphasic poly(lactic-co-glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications

Design of triphasic poly(lactic-co-glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

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