Design of New Polyacrylate Microcapsules to Modify the Water-Soluble Active Substances Release

Abstract

Despite the poor photochemical stability of capsules walls, polyacrylate is one of the most successful polymers for microencapsulation. To improve polyacrylate performance, the combined use of different acrylate-based polymers could be exploited. Herein butyl methacrylate (BUMA)-based lattices were obtained via free radical polymerization in water by adding (i) methacrylic acid (MA)/methyl methacrylate (MMA) and (ii) methacrylamide (MAC) respectively, as an aqueous phase in Pickering emulsions, thanks to both the excellent polymer shells’ stability and the high encapsulation efficiency. A series of BUMA_MA_MMA terpolymers with complex macromolecular structures and BUMA_MAC linear copolymers were synthesized and used as dispersing media of an active material. Rate and yield of encapsulation, active substance adsorption onto the polymer wall, capsule morphology, shelf-life and controlled release were investigated. The effectiveness of the prepared BUMA-based microcapsules was demonstrated: BUMA-based terpolymers together with the modified ones (BUMA_MAC) led to slow (within ca. 60 h) and fast (in around 10 h) releasing microcapsules, respectively.

Modern pancreatic islet encapsulation technologies for the treatment of type 1 diabetes

“…Установлено, что иммунопротекторные свойства агарозных гелей [8][9] можно контролировать изменением концентрации агарозы при формировании геля. Стандартно для создания капсул применяется 5% агароза, но за счет увеличения концентрации агарозы с 5% до 7,5-10% или путем нанесения на поверхность капсулы других полимеров время выживания трансплантата in vivo может быть увеличено [11]. С этой целью Dupuy et al [12] покрывали агарозные микрокапсулы полиакриламидом; другим успешным подходом было покрытие поверхности агарозы полибреном и карбоксиметилцеллюлозой (КМЦ) [13].…”

Biodegradable Microcapsules of Poly(Butylene Adipate-co-Terephthalate) (PBAT) as Isocyanate Carriers and the Effect of the Process Parameters

“…Environment and health safety, degradability, encapsulation efficiency, and biocompatibility are some features that biodegradable shells offer for a wide range of products. Natural or synthetic biodegradable polymers including ethyl cellulose [ 24 , 25 ], chitosan [ 26 , 27 ], alginate [ 28 , 29 ], polyacrylamide [ 30 , 31 ], poly(lactic acid) [ 32 , 33 ], copolymers of lactic and glycolic acids [ 34 , 35 ], or polycaprolactone [ 36 , 37 ], have been investigated as MCs shell materials for agrochemicals, drugs, or fragrances. However, their use for isocyanate encapsulation has been poorly explored.…”

Preparation and properties of soap‐free emulsion of polyacrylate grafted by polyester with highHEMAcontent

“…Polyacrylate is a kind of polymer with good photo-thermal and chemical stability, which occupies a very important position in coatings industry such as automotive and architectural coatings. [1][2][3] Since the 1960 s, with the enhancement of environmental awareness, countries around the world have successively formulated strict environmental regulations and policies to limit the emission of volatile organic compounds. 4 Water-based coatings have gradually replaced solvent-based coatings because of rich sources and the advantages of water-green, environmentally friendly, and non-polluting dispersion media.…”