Design of Gold Nanoparticles for Magnetic Resonance Imaging

Debouttiere, Pj; Roux, Stéphane; Vocanson, Francis; Billotey, Claire; Beuf, Olivier; Favre‐Réguillon, Alain; Lin, Yu-Shen; Pellet‐Rostaing, Stéphane; Lamartine, R.; Perriat, Pascal; Tillement, Olivier

doi:10.1002/adfm.200600242

Cited by 206 publications

(176 citation statements)

References 56 publications

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“…To date, CT has not been used as a molecular imaging modality because iodine cannot be conjugated to molecular proteins. Targeted nanoparticles, including superparamagnetic nanoparticles and GNPs, are now being developed to improve imaging with MRI and CT [46,47]. For instance, GNPs were conjugated to UM-A9 antibodies, which bind to the A9 (a4b6 intregin) protein which is overexpressed in many squamous cell head and neck cancers and correlates with metastatic potential [48].…”

Section: Gold Nanoparticles As Contrast Agentsmentioning

confidence: 99%

Gold nanoparticles as novel agents for cancer therapy

Jain¹,

Hirst²,

O’Sullivan³

2012

BJR

890

568

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ABSTRACT. Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-phase clinical trials. In particular, the pre-clinical evidence for gold nanoparticles as sensitisers with ionising radiation in vitro and in vivo at kilovoltage and megavoltage energies is discussed.

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Section: Gold Nanoparticles As Contrast Agentsmentioning

confidence: 99%

Gold nanoparticles as novel agents for cancer therapy

Jain¹,

Hirst²,

O’Sullivan³

2012

BJR

890

568

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“…8 Therefore, a great of efforts should be paid to develop new analytical methods with the advantages of rapid determination, high analysis flux, satisfactory sensitivity and good robustness. Thanks to the above-mentioned optical and electrochemical features, many functionalized AuNMs have been successfully synthesized [9][10][11][12][13][14] for improving performances of analytical techniques. (Figure 1) …”

Section: Introductionmentioning

confidence: 99%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

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The stability and dispersity of AuNMs in solution play a key role for the many applications. Most inorganic nanomaterials are not well dispersed in physiological buffers and require function-alization by thiols or surfactants to offer the stabilization forces. Furthermore, sufficient blood circulation time is critical for both imaging and in vivo drug delivery. Localized surface Plasmon resonance (LSPR) is one of the most significant features of AuNMs. The AuNMs as reporters have been broadly applied into lateral flow immunechromatographicalassay (LFICA) and enzyme-linked immunosorbent assay (ELISA), which is a well-established technology for analysis of the target analytes in food safety, clinical diagnosis, environmental monitoring, and medical science and so on. Au based nanomaterials (AuNMs) are known to possess many attractive features such as unique electrical, optical and catalytic properties as well as excellent biocompatibility. In this review, we summarize the current advancement on application of AuNMs in analytical sciences based on their local surface plasmon resonance, fluorescence and electrochemistry properties. AuNMs based imaging and therapy in biomolecules is explained. As one of the most reliable imaging modes, computed tomography (CT), X-ray and SERS imaging has been widely used owing to its high spatial and density resolution. We end the review by a discussion of the conjugation between gold nanoparticles with other kinds of nanoparticles such as other metals and carbon nano structures. Finally, future development in this research area is also prospected.

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“…The luminescence decreased dramatically in the presence of calcium(II), magnesium(II), zinc(II), nickel(II) and copper(II) ions, allowing interesting applications as metal sensors. 75 Another interesting example has been described by Hallet et al, 80 employing gold nanoparticles of small size (3.6 nm) coated with luminescent rhenium complexes. Surprisingly, the luminescence of the complexes was not quenched by the nanoparticles, due to the shift of the plasmon resonance to high energies as a consequence of the nanoparticles small size, thus mismatching the complex charge transfer bands.…”

Section: Assembling Coordination Compounds At Gold Nanoparticles Surfacementioning

confidence: 99%

“…Each gold nanoparticle can immobilize about 150 gadolinium complex molecules, improving the sensitivity of magnetic resonance imaging by exhibiting a much higher relaxativity as compared with the free complexes. 75 An interesting application of metal complexes is as fluorescent probes in association with gold nanoparticles. According to Thomas et al, 76 the luminescence of metal complexes at gold nanoparticles is susceptible to energy transfer from one site to the other, or quenching by the nanoparticle surface by means of energy or electron transfer, as illustrated in Figure 26.…”

Section: Assembling Coordination Compounds At Gold Nanoparticles Surfacementioning

confidence: 99%

The coordination chemistry at gold nanoparticles

Toma¹,

Zamarion²,

Toma³

et al. 2010

J. Braz. Chem. Soc.

117

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Nas nanopartículas de ouro, as propriedades químicas e físicas são ditadas principalmente pelos átomos da superfície, os quais podem interagir com espécies doadoras-aceitadoras, ou ligantes, da mesma forma que os complexos metálicos correspondentes. Além disso, os elétrons podem entrar em ressonância com a luz incidente dando origem aos plasmons de superfície, que levam à intensificação do campo elétrico local e ao efeito SERS, proporcionando uma ampla variedade de aplicações na química, biologia e nanotecnologia. Ligantes de ponte, multifuncionais, podem ser usados para intermediar a ligação de íons metálicos aos átomos de ouro da superfície. Essa estratégia permite controlar a estabilização em solução através das cargas dos complexos metálicos, acrescentando, ao mesmo tempo, novas características químicas e maior funcionalidade às nanopartículas modificadas. Dessa forma, uma nova química de coordenação pode ser vislumbrada, combinando nanopartículas metálicas, como as de ouro, e complexos, à luz da química supramolecular e dos efeitos de ressonância plasmônica de superfície.In gold nanoparticles the surface metal atoms play a major role, determining their chemical and physical properties by interacting with donor-acceptor species or ligands in a similar way as the related metal complexes. In addition, coherent oscillations of the metal electrons in resonance with the frequency of the exciting light give rise to localized surface plasmons responsible for an enhancement of the local electric field and SERS effect, allowing a wide range of applications in chemistry, biology and nanotechnology. Multifunctional bridging ligands can be employed for simultaneously binding metal ions and surface atoms. The attractive point of this approach is the possibility of exploiting the charge controlled stabilization by the metal complexes, while imparting new characteristics and properties to the modified nanoparticles. As a matter of fact, a new, exciting field of coordination chemistry can be envisaged, combining metal nanoparticles and metal complexes, in the light of supramolecular and surface plasmon resonance effects.

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Design of Gold Nanoparticles for Magnetic Resonance Imaging

Cited by 206 publications

References 56 publications

Gold nanoparticles as novel agents for cancer therapy

Gold nanoparticles as novel agents for cancer therapy

Applications of gold nanoparticles in medicine and therapy

The coordination chemistry at gold nanoparticles

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