Design of boronic acid-attributed carbon dots on inhibits HIV-1 entry

Fahmi, Mochamad Zakki; Sukmayani, W.; Khairunisa, Siti Qamariyah; Witaningrum, Adiana Mutamsari; Indriati, Dwi Wahyu; Matondang, Muhammad Qushai Yunifiar; Chang, Jia-Yaw; Kotaki, Tomohiro; Kameoka, Masanori

doi:10.1039/c6ra21062g

Cited by 74 publications

(96 citation statements)

References 52 publications

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“…Although hydroxyl and carboxylate surface groups on C-dots can inhibit HIV infection by the formation of hydrogen bonding with the molecules of the viral envelope, the boronic acid tends to enhance this effect, by interacting with 1,2-cis diol sites on gp120. 49 PEG-diamine and ascorbic acid derivate C-dots have shown encouraging results as viral inhibitors by active functionality. The dots, showing a low level of cytotoxicity with cell viability of 72% aer 48 h incubation at the concentration of 0.250 mg mL À1 , have been tested on Monkey kidney (MARC-145) and Porcine kidney (PK-15) cells.…”

Section: Antiviral Effects Of Carbon Dotsmentioning

confidence: 99%

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Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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Section: Antiviral Effects Of Carbon Dotsmentioning

confidence: 99%

“…Proposed mechanism via which CBBA/C-dots inhibit the entry of HIV-1. Reproduced with permission from ref 49…”

mentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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“…Pristine CDs have shown moderate viral blocking activity for HIV infection in vitro . 74 This has been associated with the surface of the material rich in carboxylic and hydroxyl groups prone to form noncovalent interaction with viral membranes. Moreover, due to the complexity of the biological systems these nonspecific interactions could not be so effective in vivo , likely reducing the antiviral efficacy.…”

Section: Blocking Viral Entrymentioning

confidence: 99%

Hard Nanomaterials in Time of Viral Pandemics

et al. 2020

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The SARS-Cov-2 pandemic has spread worldwide during 2020, setting up an uncertain start of this decade. The measures to contain infection taken by many governments have been extremely severe by imposing home lockdown and industrial production shutdown, making this the biggest crisis since the second world war. Additionally, the continuous colonization of wild natural lands may touch unknown virus reservoirs, causing the spread of epidemics. Apart from SARS-Cov-2, the recent history has seen the spread of several viral pandemics such as H2N2 and H3N3 flu, HIV, and SARS, while MERS and Ebola viruses are considered still in a prepandemic phase. Hard nanomaterials (HNMs) have been recently used as antimicrobial agents, potentially being next-generation drugs to fight viral infections. HNMs can block infection at early (disinfection, entrance inhibition) and middle (inside the host cells) stages and are also able to mitigate the immune response. This review is focused on the application of HNMs as antiviral agents. In particular, mechanisms of actions, biological outputs, and limitations for each HNM will be systematically presented and analyzed from a material chemistry point-of-view. The antiviral activity will be discussed in the context of the different pandemic viruses. We acknowledge that HNM antiviral research is still at its early stage, however, we believe that this field will rapidly blossom in the next period.

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“…The XPS spectrum of N 1s comprises of two peaks associated with amide/amine moieties (401 eV) and protonated amino groups (403 eV), originating from PAAm and/or PBA . XPS B 1s spectrum displays a distinct peak at 193 eV confirming the presence of PBA . On the contrary, for PEDOT:PSS film that is electropolymerized in the absence of the PBA and PAA in the reaction mixture, XPS spectra are featureless in these regions (Figure S1, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Enzyme‐Free Detection of Glucose with a Hybrid Conductive Gel Electrode

Wustoni

Savva

Sun

et al. 2018

Adv Materials Inter

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Current assays for glucose monitoring rely predominantly on glucose oxidation-catalyzing enzymes because of the high specificity of enzyme-substrate interactions. Enzymes are however expensive, suffer from instability during fabrication, operation and storage, and necessitate complex procedures for integration with transducer materials. These challenges, rendering the enzyme-based sensors disadvantageous for routine glucose monitoring, can be overcome by non-enzymatic sensors. Here, for the enzyme-free detection of glucose, an electroactive gel is developed via one-pot polymerization. The functional material is a hybrid of the conducting polymer poly(3,4-ethylenedioxythiophene):polystyrenesulfonate and a polyacrylamide gel functionalized with phenylboronic acid. As an electrode, the gel exhibits a specific current response to glucose within the standard concentration range measured in the complex bloodlike medium. When integrated as the lateral, micrometer-scale gate electrode of an organic electrochemical transistor (OECT), the channel current is proven to be sensitive to the presence of glucose in the measurement solution. The advantage of the OECT based sensor compared to the amperometric electrode is its miniaturized form, amplified input signal as well the elimination of a reference electrode. Adaptable to different geometries, this conducting gel exhibits multifunctionality within its soft, gel-like architecture, that is, mixed ionic and electronic conductivity and glucose specific electrical response. 2 IntroductionGlucose is the primary nutrient of living systems to perform a variety of cellular metabolic processes including cellular respiration and biosynthesis. [1,2] In case of malfunction, cells may end up not taking up glucose sufficiently, which leads to abnormal levels of glucose build up in the bloodstream. The high concentration of glucose in blood is typically associated with the disease, diabetes. Diabetes is a pandemic disorder which was one of the top ten leading causes of death worldwide in 2015 and it is predicted to become the tenth most burdensome disease by 2030. [3][4][5] A good part of diabetes treatment as well as its early diagnosis involve self-monitoring of the amount of glucose in biological fluids. Thus, powerful, low-cost and easy-to-use glucose sensors are on high demand.The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. The majority of current glucose sensors are thus electronic and based on the redox enzyme, glucose oxidase that undergoes redox reactions with the analyte, glucose. In these platforms, the enzyme transforms glucose into gluconolactone and hydrogen peroxide (H2O2). H2O2 reacts with a metal electrode in its vicinity, resulting in a change in the flow of electrical current which is directly proportional to concentration of glucose that has reacted with the enzyme. The electrical potential required to oxidize H2O2 however matches that for the oxidation of several ...

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Design of boronic acid-attributed carbon dots on inhibits HIV-1 entry

Abstract: The development of gp120 targeted human immunodeficiency virus (HIV) drug has improved antiretroviral therapies owing to its effects on attachment to target cells.

Cited by 74 publications

References 52 publications

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Hard Nanomaterials in Time of Viral Pandemics

Enzyme‐Free Detection of Glucose with a Hybrid Conductive Gel Electrode

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