Design of a wideband multi-channel system for time reversal hyperthermia

Trefná, Hana Dobšíček; Togni, Paolo; Shiee, Reza; Vrba, Jan

doi:10.3109/02656736.2011.641655

Cited by 18 publications

(10 citation statements)

References 32 publications

(53 reference statements)

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“…Parameters studied for phased arrays are intensity, i.e. amplitude or power, and phase-differences between the antenna drive signals (30-33). Further, variation in the position of the patient relative to the antenna array has been shown to be critically important (34).…”

Section: Power Absorption Simulation Techniquesmentioning

confidence: 99%

Simulation techniques in hyperthermia treatment planning

Paulides

Stauffer

Neufeld

et al. 2013

International Journal of Hyperthermia

168

128

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Clinical trials have shown that hyperthermia (HT), i.e. an increase of tissue temperature to 39-44°C, significantly enhance radiotherapy and chemotherapy effectiveness (1). Driven by the developments in computational techniques and computing power, personalized hyperthermia treatment planning (HTP) has matured and has become a powerful tool for optimizing treatment quality. Electromagnetic, ultrasound, and thermal simulations using realistic clinical setups are now being performed to achieve patient-specific treatment optimization. In addition, extensive studies aimed to properly implement novel HT tools and techniques, and to assess the quality of HT, are becoming more common. In this paper, we review the simulation tools and techniques developed for clinical hyperthermia, and evaluate their current status on the path from “model” to “clinic”. In addition, we illustrate the major techniques employed for validation and optimization. HTP has become an essential tool for improvement, control, and assessment of HT treatment quality. As such, it plays a pivotal role in the quest to establish HT as an efficacious addition to multi-modality treatment of cancer.

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Section: Power Absorption Simulation Techniquesmentioning

confidence: 99%

Simulation techniques in hyperthermia treatment planning

Paulides

Stauffer

Neufeld

et al. 2013

International Journal of Hyperthermia

168

128

View full text Add to dashboard Cite

show abstract

“…This PLL-based phase shifting approach showed substantial improvement in flexibility, resolution, feasibility and accuracy over other approaches such as standalone phase shifter based and modulation-based phase shifting. For example, an 8-bit digital phase shifter (DST-10-480/1S, Pulsar Microwave, Clifton, NJ, USA) was used in an experimental setup [ 44 ]. It can only generate 256 phases and covers a limited frequency range.…”

Section: Discussionmentioning

confidence: 99%

“…To summarize, advancing high-fidelity RF hyperthermia requires pioneering strategies that exploit a wider range of RF frequencies and high-density RF antenna arrays with miniaturized RF building blocks that permit independent frequency, amplitude and phase control for each channel. Hardware implementations for RF heating typically operate at a fixed frequency and have a limited number of RF channels [ 10 , 32 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Recognizing these opportunities and challenges, this work reports on the design, implementation, evaluation, validation and application of a 32-channel modular signal generator (SG PLL ) that uses phase-locked loop (PLL) circuit blocks and permits high amplitude, phase and frequency tuning resolution.…”

Section: Introductionmentioning

confidence: 99%

Design, Implementation, Evaluation and Application of a 32-Channel Radio Frequency Signal Generator for Thermal Magnetic Resonance Based Anti-Cancer Treatment

Han

Eigentler

Wang

et al. 2020

Cancers

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Thermal Magnetic Resonance (ThermalMR) leverages radio frequency (RF)-induced heating to examine the role of temperature in biological systems and disease. To advance RF heating with multi-channel RF antenna arrays and overcome the shortcomings of current RF signal sources, this work reports on a 32-channel modular signal generator (SGPLL). The SGPLL was designed around phase-locked loop (PLL) chips and a field-programmable gate array chip. To examine the system properties, switching/settling times, accuracy of RF power level and phase shifting were characterized. Electric field manipulation was successfully demonstrated in deionized water. RF heating was conducted in a phantom setup using self-grounded bow-tie RF antennae driven by the SGPLL. Commercial signal generators limited to a lower number of RF channels were used for comparison. RF heating was evaluated with numerical temperature simulations and experimentally validated with MR thermometry. Numerical temperature simulations and heating experiments controlled by the SGPLL revealed the same RF interference patterns. Upon RF heating similar temperature changes across the phantom were observed for the SGPLL and for the commercial devices. To conclude, this work presents the first 32-channel modular signal source for RF heating. The large number of coherent RF channels, wide frequency range and accurate phase shift provided by the SGPLL form a technological basis for ThermalMR controlled hyperthermia anti-cancer treatment.

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“…An analysis of the algorithm sensitivity to specific disturbances is carried out by means of simulations, using the commercially available software CST Studio (Dassault Systmes). Finally, the proof-of-concept is demonstrated experimentally using the Head & Neck MW-HT prototype system developed at Chalmers University of Technology [3].…”

Section: Introductionmentioning

confidence: 99%

Self-calibration algorithms for microwave hyperthermia antenna arrays

Zanoli

Trefná

2018

12th European Conference on Antennas and Propagation (EuCAP 2018)

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In deep microwave hyperthermia (MW-HT), antenna arrays are used to generate an interference pattern which focuses energy in the tumor location. These arrays are subject to a number of disturbances which must be compensated for through calibration. This paper proposes and analyzes a pair of self-calibration algorithms, i.e. calibration procedures which rely only on S-matrix measurements of the N-port array applicator device, avoiding the need for external references and making real-time in-treatment calibration possible. Two algorithms are analyzed by means of simulations and experiments in terms of reliability and sensitivity to different kinds of disturbances. The results show that one of two implemented algorithms can converge to the same calibration values obtained when using an external calibration reference (monopole antenna).

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Design of a wideband multi-channel system for time reversal hyperthermia

Cited by 18 publications

References 32 publications

Simulation techniques in hyperthermia treatment planning

Simulation techniques in hyperthermia treatment planning

Design, Implementation, Evaluation and Application of a 32-Channel Radio Frequency Signal Generator for Thermal Magnetic Resonance Based Anti-Cancer Treatment

Self-calibration algorithms for microwave hyperthermia antenna arrays

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