“…On the contrary, electrochemistry has always provided analytical techniques characterized by instrumental simplicity, moderate cost, and portability [11]. In particular, ion-selective electrodes (ISEs) in pharmaceutical analysis have increased in prominence due to the advantages of portability, low energy consumption, limited sample pretreatment, rapidity, non-destructibility, adaptability to ϯ small sample volumes and on-line monitoring [12,13]. Thus, the development of reliable ISEs offering these advantages for the determination of the studied drugs is desirable, especially given that the literature did not reveal any previous analyses of PAN or ITH using ISEs.…”