Design of a microfluidic paper-based device for the quantification of phenolic compounds in wine samples

Martínez-Pérez-Cejuela, Héctor; Mesquita, Raquel B. R.; Couto, José António; Simó‐Alfonso, Ernesto Francisco; Herrero‐Martínez, José Manuel; Rangel, António O. S. S.

doi:10.1016/j.talanta.2022.123747

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…Paper-based microfluidics can be precisely adjusted to meet various needs by varying various paper characteristics such as thickness, porosity, roughness, and wettability. [38][39][40] Patterned paper is ideal for low-cost, portable, and technically simple multiplexed bioassays. [41][42][43][44] Paper-based microfluidics offer many unique advantages over conventional microfluidics in terms of unpowered fluid transport via capillary action, high surface area to volume ratio for chemical reactions and assays, and the ability to store reagents in an active form within the fiber network.…”

Section: Papermentioning

confidence: 99%

“…For example, Raquel B. R. Mesquita et al described a paper-based microfluidic for the quantification of total phenolic compounds in wines with the top layer consisting of 24 papers (Whatman® 541, pore size 20-25 μm, thickness 160 μm) and the bottom layer consisting of 24 papers (Whatman® 3, pore size 6 μm, thickness 390 μm). 40 In summary, paper is known as an interlaced network of cellulose fibers that wicks fluids by capillarity. As a kind of hydrophilic and pump-less material, which is discussed when talking about its advantages, paper is extremely suitable to generate microfluidics.…”

Section: Papermentioning

confidence: 99%

Section: Papermentioning

confidence: 99%

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Paper-based microfluidics in sweat detection: from design to application

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Section: Papermentioning

confidence: 99%

Section: Papermentioning

confidence: 99%

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Paper-based microfluidics in sweat detection: from design to application

Yuan

Zhan

et al. 2023

Analyst

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“…Device miniaturization has attracted increasing interest as testing tool based on the portability and low cost of analytical systems, easy to use, and the possibility of rapid on-site analysis [ 1 ]. Among all the possible miniaturized platforms, paper-based materials are of special interest due to the intrinsic nature of this cellulosic support [ 2 , 3 ], for instance, availability, easy derivatization, lightweight, and capillary forces without the need of external propulsion forces [ 4 ]. However, the functionalization of the cellulose surface must be performed in order to adapt its properties to the target analyte/s, combining the benefits provided by the cellulose and improved properties of functional materials [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Micro-paper-based analytical device decorated with metal-organic frameworks for the assay of synthetic cannabinoids in oral fluids coupled to ion mobility spectrometry

Martínez-Pérez-Cejuela

García-Atienza

Simó‐Alfonso

et al. 2023

Microchim Acta

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A new concept of paper-based device has been developed combining the advantages of cellulose supports and the rich surface chemistry of metal-organic frameworks (MOFs). The composite, named as NH2-UiO-66@paper, has been developed for the isolation of synthetic cannabinoid receptor agonists (SCRAs) in oral fluids, trying to mimic the interactions of those compounds with the human CB1R and CB2R receptors, mainly governed by hydrogen bonding and π-interactions with serine and histidine residues. MOF selection (UiO-66) and functionalization of the ligand (2-aminoterephthalic acid) has been done according to the following criteria: (i) water stability of the selected MOF, and (ii) promoting appropriate interactions with SCRAs due to the MOF nature. NH2-UiO-66@paper composite has been characterized in depth and the results confirmed that the material is stable at the temperature selected for thermal desorption (230 °C). Furthermore, the developed method provided appropriate precision values (RSD < 12%) and a limit of detection as low as 10 ng using ion mobility spectrometry as analytical technique. Lastly, the method has been successfully applied to the isolation of several synthetic cannabinoids from oral fluids. This method claims to be an interesting approach for expanding the combination of MOFs with sustainable support and represents a promising alternative to sophisticated and non-portable systems due to the negligible sample treatment required and the simplicity of the operation, which can be applied with screening purposes. Graphical abstract

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Combining microfluidic paper-based platform and metal–organic frameworks in a single device for phenolic content assessment in fruits

Martínez-Pérez-Cejuela

Mesquita

Simó‐Alfonso

et al. 2023

Microchim Acta

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A microfluidic paper-based device (µPAD) has been combined with metal–organic frameworks (MOFs) for total phenolic compounds (TPC) quantification in fruit samples for the first time. The performance of the µPAD, based upon the vertical flow approach, was enhanced in order to determine the TPC content with high accuracy in fruit samples. The method was based on the traditional Folin-Ciocalteu Index using gallic acid or oenotannin as reference phenolic compounds. This novel design and construction of the device are in agreement with the principles of Green Chemistry avoiding wax technology (lower toxicity). The analytical parameters that affect the colorimetric method (using digital imaging of the colored zone) performance were optimized including design, sample volume, and MOF amount. Then, the analytical features of the developed method were investigated such as dynamic range (1.6–30 mg L−1), limit of detection (0.5 mg L−1), and precision (RSD < 9%). Besides, the in-field analysis is achievable with a color stability up to 6 h after the loading process of the sample and storage stability for at least 15 days without performance losses (under vacuum at − 20 °C). Furthermore, the MOF ZIF-8@paper was characterized to study its composition and the successful combination. The feasibility of the proposed method was demonstrated by determining the TPC in 5 fruit samples using oenotannin as reference solute. The accuracy was validated by comparison of the data with the results obtained with the recommended protocol proposed by the International Organisation of Vine and Wine (OIV). Graphical Abstract

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Design of a microfluidic paper-based device for the quantification of phenolic compounds in wine samples

Cited by 9 publications

References 30 publications

Paper-based microfluidics in sweat detection: from design to application

Paper-based microfluidics in sweat detection: from design to application

Micro-paper-based analytical device decorated with metal-organic frameworks for the assay of synthetic cannabinoids in oral fluids coupled to ion mobility spectrometry

Combining microfluidic paper-based platform and metal–organic frameworks in a single device for phenolic content assessment in fruits

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