Design of a Mems device for studying cell migration and differentiation

Torres, Iván; Eland, Luci; Redfern, Christopher P.F.; Hedley, John

doi:10.1109/icsens.2017.8233948

Cited by 1 publication

(1 citation statement)

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“…Hydroxylation of the microfluidic channels results in irreversible bonding of the microfluidic chip's layers (specifically when the device is made of PDMS or glass) due to the chemical reaction between the hydroxyl groups at the interface of the top and bottom layers. Since the hydroxylation techniques are adaptable with many surfaces such as glass, polymers including PDMS, silicon, and aluminum, a variety of substrates could be biofunctionalized using silane coupling agents …”

Section: Glass‐based Microfluidic Devicesmentioning

confidence: 99%

Biofunctionalization of Glass‐ and Paper‐Based Microfluidic Devices: A Review

Shakeri

Jarad

Leung

et al. 2019

Adv Materials Inter

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Biofunctionalization of microchannels is of great concern in the fabrication of microfluidic devices. Different substrates such as glass slides, papers, polymers, and beads require different biofunctionalization approaches granting the utilization of microfluidics in several biomedical applications. Covalent immobilization of biomolecules inside the microchannels is achieved by chemical modification of the surface such as silanization or introducing different coupling agents. Although creating biointerfaces that are covalently bonded to the microchannel surface necessitates multiple steps of surface modification and incubation times, it bestows a robust biointerface capable of withstanding high shear stresses and harsh conditions without dissipating the biofunctionality. Regarding the applications that do not require robustness and long‐term stability, noncovalent attachment of biomolecules such as van der Waals and hydrophobic interactions are adequate to successfully create a functional biointerface. This review summarizes the various biofunctionalization approaches used in the most common microfluidic substrates: glass and paper. In addition, several biofunctionalization examples are proposed and described in detail along with their associated applications.

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Section: Glass‐based Microfluidic Devicesmentioning

confidence: 99%