Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials

García, Ana; Cabañas, M.V.; Peña, J. L.; Sánchez‐Salcedo, Sandra

doi:10.3390/pharmaceutics13111981

Cited by 21 publications

(18 citation statements)

References 170 publications

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“…high surface to volume ratio, reactivity and biomimetic morphologies compared to the bulk counterpart due to quantum size effects and surface phenomena at the nanoscale. HAP nanocrystals can be used for example in tissue engineering, nanomedicine, industrial catalysis and in orthopaedic implant coating [22,23]. In addition, HAP nanospheres, thanks to their low solubility in physiological conditions, can be used as carriers for controlled and local drug delivery both by surgical placement and injection [24,25].…”

Section: Introductionmentioning

confidence: 99%

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Rocca

Rinaldi

Bruni

et al. 2022

J Inorg Organomet Polym

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In the pharmaceutical market, the need to find effective systems for the efficient release of poorly bioavailable drugs is a forefront topic. The inorganic–organic hybrid materials have been recognized as one of the most promising systems. In this paper, we developed new Hydroxypapatite@Furosemide hybrids with improved dissolution rates in different media with respect to the drug alone. The hybrids formation was demonstrated by SEM/EDS measurements (showing homogeneous distribution of the elements) and FT-IR spectroscopy. The drug was adsorbed onto hydroxyapatite surfaces in amorphous form, as demonstrated by XRPD and its thermal stability was improved due to the absence, in the hybrids, of melting and decomposition peaks typical of the drug. The Sr substitution on Ca sites in hydroxyapatite allows increasing the surface area and pore volume, foreseeing a high capacity of drug loading. The dissolution tests of the hybrid compounds show dissolution rates much faster than the drug alone in different fluids, and also their solubility and wetting ability is improved in comparison to furosemide alone.

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Section: Introductionmentioning

confidence: 99%

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Rocca

Rinaldi

Bruni

et al. 2022

J Inorg Organomet Polym

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“…The chemical composition of synthetic scaffolds for bone regeneration usually includes hydroxyapatite (HAp) and β-tricalcium phosphate (TCP). − However, HAp is not well resorbed and remains in the body . Conversely, β-TCP resorption is excessively fast, and its function as a scaffold declines before a sufficient bone volume is reached .…”

mentioning

confidence: 99%

Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System

et al. 2022

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Although studies on scaffolds for tissue generation have mainly focused on the chemical composition and pore structure, the effects of scaffold shape have been overlooked. Scaffold shape determines the scaffold surface area (SA) at the single-scaffold level (i.e., microscopic effects), although it also affects the amount of interscaffold space in the tissue defect at the whole-system level (i.e., macroscopic effects). To clarify these microscopic and macroscopic effects, this study reports the osteogenesis abilities of three types of carbonate apatite granular scaffolds with different shapes, namely, irregularly shaped dense granules (DGs) and two types of honeycomb granules (HCGs) with seven hexagonal channels (∼255 μm in length between opposite sides). The HCGs possessed either 12 protuberances (∼75 μm in length) or no protuberances. Protuberances increased the SA of each granule by 3.24 mm 2 while also widening interscaffold spaces and increasing the space percentage in the defect by ∼7.6%. Interscaffold spaces were lower in DGs than HCGs. On DGs, new bone formed only on the surface, whereas on HCGs, bone simultaneously formed on the surface and in intrascaffold channels. Interestingly, HCGs without protuberances formed approximately 30% more new bone than those with protuberances. Thus, even tiny protuberances on the scaffold surface can affect the percentage of interscaffold space, thereby exerting dominant effects on osteogenesis. Our findings demonstrate that bone regeneration can be improved by considering macroscopic shape effects beyond the microscopic effects of the scaffold.

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“…As can be seen, macropores appropriate for cell accommodation, proliferation, and vascularization were confirmed to be introduced into all of the samples using the PMMA template. Besides macroporosity, mesoporosity plays a significant role in bone regeneration, especially in the release of the biological agents and enhancing the surface activity and bioactivity [36].…”

Section: In Vitro Bioactivity Assessmentmentioning

confidence: 99%

Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

et al. 2022

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Finding innovative solutions to improve the lives of people affected by trauma, bone disease, or aging continues to be a challenge worldwide. Tissue engineering is the most rapidly growing area in the domain of biomaterials. Cerium-containing MBG-derived biomaterials scaffolds were synthesized using polymethyl methacrylate (PMMA) as a sacrificial template. The obtained scaffolds were characterized by X-ray powder diffraction (XRPD), infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The Ce4+/Ce3+ ratio in the scaffolds was estimated. In vitro testing revealed good cytocompatibility of the investigated scaffolds in mouse fibroblast cell line (NCTC clone L929). The results obtained regarding bioactivity, antibacterial activity, and controlled drug delivery functions recommend these scaffolds as potential candidates for bone tissue engineering applications.

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Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials

Cited by 21 publications

References 170 publications

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System

Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

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