Design and Synthesis of Novel Benzoazepinone Derivatives as Potent Estrogen Receptor Alpha Inhibitors
N.V.S. Venugopal,
Nizampatnam,
S. Tirumala Jagadeesh
Abstract:Background
Selective estrogen receptor modulators (SERMs) block the effects of estrogen on breast cancer cells by sitting in the estrogen receptors. If a SERM is in the estrogen receptor, estrogen can't attach to the cancer cell and the cell doesn't receive estrogen's signals to grow and multiply. The goal of this research is to develop small drug-like molecules of novel Benzoazepinone derivatives that mimic the ability of the SERM (Tamoxifene and Raloxifene) to binds with estrogen receptor protein.
Methods
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