Design and synthesis of new adamantyl derivatives as promising antiproliferative agents

Shahin, Afnan I.; Zaraei, Seyed–Omar; AlKubaisi, Bilal O.; Ullah, Saif; Anbar, Hanan S.; El-Gamal, Randa; Menon, Varsha; Abdel‐Maksoud, Mohammed S.; Oh, Chang‐Hyun; El‐Awady, Raafat; Gelsleichter, Nicolly Espindola; Pelletier, Julie; Sévigny, Jean; Iqbal, Jamshed; Al‐Tel, Taleb H.; El‐Gamal, Mohammed I.

doi:10.1016/j.ejmech.2022.114958

Cited by 6 publications

(3 citation statements)

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“…using the reference drug (doxorubicin). [47] Compounds 2a and 2b were screened toward normal breast epithelial cells, HME1, and normal skin fibroblast cells, F180. Compounds 2a and 2b produced no cytotoxic effect toward normal cells (HME1 and F180) and were docked inside the active sites of NPP2, NPP3, and carbonic anhydrase (II, IX, and XII).…”

Section: Rudolfova Et Al Have Synthesized a Library Of Purine Nucleos...mentioning

confidence: 99%

“…Shahin et al have synthesized a novel class of hybrids containing adamantyl carboxamide and sulfonate or sulfonamide moieties (Table 1), which were evaluated for antiproliferative activity toward cancer cell line panel (NCI‐60) using the reference drug (doxorubicin). [ 47 ] Compounds 2a and 2b were screened toward normal breast epithelial cells, HME1, and normal skin fibroblast cells, F180. Compounds 2a and 2b produced no cytotoxic effect toward normal cells (HME1 and F180) and were docked inside the active sites of NPP2, NPP3, and carbonic anhydrase (II, IX, and XII).…”

Section: Pharmacological Activities Of Adamantane‐based Hybridsmentioning

confidence: 99%

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Nascent pharmacological advancement in adamantane derivatives

Ragshaniya,

Kumar,

Tittal

et al. 2023

Archiv der Pharmazie

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The adamantane moiety has attracted significant attention since its discovery in 1933 due to its remarkable structural, chemical, and medicinal properties. This molecule has a notable impact in the therapeutic field because of its “add‐on” lipophilicity to any pharmacophoric moieties. As in the case of molecular hybridization, in which one pharmacophore is attached to another one(s) with a probability of increasing the biological activity, adding an adamantane unit improves the absorption distribution, metabolism and excretion properties of the resultant hybrid molecule. This review summarizes various reports highlighting the biological activities of adamantane‐based synthetic compounds and their structure–activity relationship study. The information presented in this review may open up possible dimensions for adamantane‐based drug development and discovery in the pharmaceutical industry after proper structural modifications.

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Section: Rudolfova Et Al Have Synthesized a Library Of Purine Nucleos...mentioning

confidence: 99%

Section: Pharmacological Activities Of Adamantane‐based Hybridsmentioning

confidence: 99%

Nascent pharmacological advancement in adamantane derivatives

Ragshaniya,

Kumar,

Tittal

et al. 2023

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

“…52 One such non-nucleotide class of inhibitors is a variety of sulfonates reported active against the ectonucleotidases with K i values in low micro-molar ranges. [57][58][59][60][61] Sulfonates have been reported to be anticancer agents with additional therapeutic potentials. Since 1959, persistent myeloid leukaemia, refractory lymphoma and myeloproliferative ailments have all been treated with busulfan, one of the alkyl sulfonate.…”

Section: Introductionmentioning

confidence: 99%