Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK

IKKβ inhibitors identification part II: Ligand and structure-based virtual screening

“…A total of seven compounds [25][26][27][28][29] were used in a common feature model generation (Fig. 8).…”

Theoretical and experimental vibrational spectroscopic study of 4-(1-Pyrrolidinyl)piperidine

“…This molecule has been identified as good inhibitor of IKK2 (IjB kinase) and used to synthesize some potent CCR4 antagonists and substituted guanidines [1][2][3]. It has also been used in the study of carbon-14 labelling of 3-cyanoquinolines systems [4].…”

Improvement of ventilation-induced lung injury in a rodent model by inhibition of inhibitory κB kinase

“…10 IKK 16 is a novel specific IKK inhibitor 11 and has shown its beneficial effect on sepsis. 7 However, it remains unknown whether the IKK 16 has any protective effect on VILI, a noninfectious caused lung injury.…”