2018
DOI: 10.1021/acs.cgd.7b01618 View full text |Buy / Rent full text
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Abstract: Continuous crystallization processes achieving the complete resolution of racemic feed mixtures of conglomerate forming substances are presented. The processes considered rely on the principles of preferential crystallization or attrition-enhanced deracemization (Viedma ripening). A single mechanistic population balance model is shown to describe both operating modes. For the case of isothermal Viedma ripening, a shortcut method is introduced that allows the rapid and computationally efficient design of proces… Show more

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“…Traditionally, this may have been difficult to implement industrially in the pharmaceutical industry which has almost exclusively utilized standard batch equipment. However, the past decade has seen a significant uptake of crystallizer technologies for use in next generation continuous pharmaceutical platforms with ability to separate enantiomers in a continuous manner as well as access to a wider ranges of particle sizes, improved polymorph control, and increased purity …”
Section: Introductionmentioning
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“…Traditionally, this may have been difficult to implement industrially in the pharmaceutical industry which has almost exclusively utilized standard batch equipment. However, the past decade has seen a significant uptake of crystallizer technologies for use in next generation continuous pharmaceutical platforms with ability to separate enantiomers in a continuous manner as well as access to a wider ranges of particle sizes, improved polymorph control, and increased purity …”
Section: Introductionmentioning
“…, describing the number of fragments of size L formed when breaking a particle of size λ was chosen as: [50][51][52][53]…”
Section: Process Modelmentioning
“…Therefore, chiral resolution, the separation of a racemic (equimolar) mixture into its enantiomers, is the most widely used approach to produce preferred enantiomers. Many of the available resolution techniques such as chromatography [4][5][6][7] and membrane separation [8][9][10], typically deliver the product in diluted form in the liquid phase often requiring a crystallization step for producing the desired solid product [11]. In contrast, preferential crystallization can be directly used as an attractive and efficient means to separate the racemic mixtures due to its ability to provide high purity solid products.…”
Section: Introductionmentioning