This chapter is aimed to address the performance of compact heat exchangers with offset strip fin, which have been studied by the researchers in detail for decades. The history and basic features of offset strip fins (OSF) are described first to introduce the fin geometry. Then, the effect of the fin geometry on the performance of the offset strip fin is given from experimental and numerical aspects, respectively. Flow streams evolution under varying offset strip geometries is summarized in order to demonstrate the physical impact on the flow. The thermohydraulic features of the flow in the offset strip fin are investigated by considering the Colburn j-factor and friction (f) factors in diverse flow regimes. Furthermore the criteria, flow area goodness factor j/f, the ratio j/f 1/3 and thermohydraulic performance factor JF, derived from the mentioned dimensionless factors, are also used as a scale of the performance of the structure and reported in the chapter.