Design and Fabrication of Plasmonic Nanostructures with DNA for Surface‐Enhanced Raman Spectroscopy Applications

Abstract

Plasmonic nanostructures display unique and strongly enhanced optical properties, therefore hold great promise for a wide range of spectroscopic applications, particularly surface-enhanced Raman spectroscopy (SERS). It is well acknowledged that the major contributions to SERS arise from molecules positioned in nanojunctions where the optical field is intensively concentrated due to localized surface plasmon excitations. One of the key challenges in SERS therefore lies in the design and fabrication of plasmonic nanostructures with controllable nanojunctions. In recent years, by exploiting the unparalleled base-pairing self-recognition properties, DNA-mediated assembly has emerged as a powerful and programmable tool for the accurate construction of complex and hierarchical plasmonic nanostructures with well-defined geometry and topology. In this review, we will summarize recent advances on design and fabrication of a rich variety of plasmonic nanostructures by virtue of DNA nanotechnology, and discuss their optical properties as well as applications in SERS.

Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

“…The results demonstrated that chitosan functionalized on the surface of GO showed low cytotoxicity greatly and improved biocompatibility. Surface functionalization of GO with macromolecules has been reported to remarkably attenuate its cytotoxic effects [ 45 ]. Hu et al reported that fetal bovine serum in cell medium markedly decreased the cell cytotoxicity of GO in non-small cell lung cancer A549 cells [ 46 ].…”