Design and fabrication of implantable pressure sensing resistor sensor for human bladder monitoring system

Kim, Jong-Hyun; Choi, Byungcho

doi:10.1007/s00542-011-1336-5

Cited by 4 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mucosa of the bladder, or urothelium, is the compliant lining of the inner wall and is thought to be sturdy enough to encapsulate and entrap small sensor devices, while being sufficiently compliant to enable bladder pressure measurement submucosally. 37 Devices that are submucosally implanted into the bladder involve a more invasive procedure than intravesical devices but may be more suitable for chronic use, as they are shielded from urine and therefore less likely to cause urine stone formation. Early attempts to develop implantable pressure sensors have struggled with sensor migration and infection in dogs and goats.…”

Section: Introductionmentioning

confidence: 99%

Is submucosal bladder pressure monitoring feasible?

Basu

Majerus

Ferry

et al. 2018

Proc Inst Mech Eng H

View full text Add to dashboard Cite

Introduction: There has been recent interest in placing pressure sensing elements beneath the bladder mucosa to facilitate chronic bladder pressure monitoring. Wired submucosal sensors with the wires passed through detrusor have been demonstrated in vivo, with limited chronic retention, potentially due to the cable tethering the detrusor. Published studies of submucosal implants have shown that high correlation coefficients between submucosal and lumen pressures can be obtained in caprine, feline, and canine models. We have developed a wireless pressure monitor and surgical technique for wireless submucosal implantation and present our initial chronic implantation study here. Methods: Pressure monitors were implanted (n=6) in female calf models (n=5). Five devices were implanted cystoscopically with a 25-Fr rigid cystoscope. One device was implanted suprapubically to test device retention with an intact mucosa. Wireless recordings during anesthetized cystometry simultaneous with catheter-based reference vesical pressure measurements during filling and manual bladder compressions were recorded. Results: Individual analysis of normalized data during bladder compressions (n=12) indicated high correlation (r=0.85–0.94) between submucosal and reference vesical pressure. The healing response was robust over 4 weeks; however, mucosal erosion occurred 2–4 weeks after implantation, leading to device migration into the bladder lumen and expulsion during urination. Conclusions: Wireless pressure monitors may be successfully placed in a suburothelial position. Submucosal pressures are correlated with vesical pressure, but may differ due to biomechanical forces pressing on an implanted sensor. Fully wireless devices implanted beneath the mucosa have risk of erosion through the mucosa, potentially caused by disruption of blood flow to the urothelium, or an as-yet unstudied mechanism of submucosal regrowth. Further investigation into device miniaturization, anchoring methods, and understanding of submucosal pressure biomechanics may enable chronic submucosal pressure monitoring. However, the risk of erosion with submucosal implantation highlights the need for investigation of devices designed for chronic intravesical pressure monitoring.

show abstract

Section: Introductionmentioning

confidence: 99%