Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer’s

N-Phenacylthiazolium Salts as Inhibitors of Cholinesterases

“…2,4-Substituted thiazoles [19][20][21] including thiazole drug acotiamide [22] as well as derivatives of benzothiazole, [23,24] thiazolopyrimidine, [25] and thiazolotriazinone [26,27] can exhibit inhibitory properties against…”

Synthesis and Evaluation of A New Series of Thiazolyl-Pyrazoline Derivatives as Cholinesterase Inhibitors

“…11 Diverse modifications of the thiazole ring at various positions have led to a variety of thiazole-based CNS agents as AChE and BuChE inhibitors, secretase inhibitors, monoamine oxidase (MAO) inhibitors, neuronal nitric oxide synthase inhibitors, ACh receptor ligands, adenosine receptor ligands, dopamine receptor ligands, serotonin receptor ligands, glutamate receptor ligands, ɣ-aminobutyric acid receptor ligands, opioid receptor ligands, neuroprotective and anticonvulsant agents. [11][12][13][14] Acotiamide has been reported to be a promising thiazole-based agent for the treatment of functional dyspepsia in clinical trials. Acotiamide enhances ACh release in the enteric nervous system through AChE inhibition and M1/M2 muscarinic receptor antagonism.…”

Synthesis, characterization, in vitro antiproliferative and cytotoxicity effects of a new class of 2-((1R,2S)-2-((E)-4-substitutedstyryl) cyclooctyl)benzo[d]thiazole derivatives

“…Thiazole ring found in many natural compounds such as vitamin B1 (thiamine), penicillin and carboxylase. 1,2 Terrestrial and marine compounds with different biological activities that represent a very important field in drug discovery. 3,4 Many drugs such as Sulfathiazole, Ritonavir, Abafungin, Bleomycin and Tiazofurin contain thiazol moiety.…”

“…Furthermore, 1,3-thiazole and 1,3-benzothiazoles possess important biological properties such as distinctive antifungal, antimicrobial, antitubercular, anticancer, anti-angiogenic, antiproliferative and cytotoxic activity. [19][20][21][22] In view of the above mentioned facts, we report herein the synthesis, in vitro cytotoxic evaluation of some novel 2-strylcyclooctlyl substituted 1,3-benzothiazole derivatives.…”