Design and development of a stable polyherbal formulation based on the results of compatibility studies

Bhope, S. G.; Nagore, Dheeraj; Kuber, V. V.; Gupta, Pankaj; Patil, M. J.

doi:10.4103/0974-8490.81960

Cited by 35 publications

(30 citation statements)

References 24 publications

(24 reference statements)

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“…Moreover, many dangerous and lethal side effects have recently been reported, including direct toxic effects, allergic reactions, effects from contaminants and interactions with herbal drugs [2] . In view of the above, standardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply, a quality assurance program for production and manufacturing of an herbal drug [3] .…”

Section: Research Papermentioning

confidence: 99%

Analytical Standards of Amrtadi Churna: A Classical Ayurvedic Formulation

Mukhi¹,

Bose²,

Ray³

et al. 2017

Journal of Pharmaceutical Sciences

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The present investigation was carried out to characterise the Ayurvedic preparation, Amrtadi churna, a polyherbal formulation comprising of three ingredients, on the basis of the pharmacognostic, physicochemical, pharmaceutical, microbiological, toxicological, spectroscopic and chromatographic parameters to confirm its identity, quality and purity. The results obtained in this evaluation demonstrated the potential to identify each and every ingredient in Amrtadi churna. The parameters documented in this paper could be used for the preparation of the monograph on quality standards for Amrtadi churna to maintain its batch-to-batch consistency. This document could also be utilised for Fourier transform infrared spectroscopy and high performance thin layer chromatography based rapid authentication for the formulation.

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Section: Research Papermentioning

confidence: 99%

Analytical Standards of Amrtadi Churna: A Classical Ayurvedic Formulation

Mukhi¹,

Bose²,

Ray³

et al. 2017

Journal of Pharmaceutical Sciences

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“…The herbomineral tablets were evaluated for various parameters like appearance, thickness, weight variation, hardness and friability [14].…”

Section: Post-compression Studies Of Prepared Herbomineral Tabletsmentioning

confidence: 99%

“…The discs were introduced over each tablet to avoid their floating of the tablets in the medium. The apparatus was operated until all the tablets were disintegrated [14].…”

Section: Disintegration Timementioning

confidence: 99%

Formulation of Polyherbomineral Matrices for Treatment of Osteoporosis

Mulchand¹,

Seema²

2018

Asian J Pharm Clin Res

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Objective: Herbal drugs are finding the new source of promising drugs for the treatment and cure of various ailments. The present research work deals with the formulation and evaluation of herbomineral formulation indicated for osteoporosis. Materials and Methods:The aqueous extract of Terminalia arjuna (ARJ), Asthisamhara (ASTM), Gokhru (GKH), Ashwagandha (ASG) and dried powder of drugs Sunthi (ST), Padmakashta (PDMS), Laksha (PLSH) and Jestamadha were prepared and formulated into a herbomineral tablet with organic calcium viz.; Godanti Bhasma (Godan) and Kukkutandatvak Bhasma (Kukk) by wet granulation. Results:The prepared tablets were evaluated for various parameters such as colour, average weight, hardness, friability and disintegration time, which were found acceptable as per pharmacopoeial specifications. The weight variation (450 mg±10%), pH (4.58), disintegration time (17 min) and hardness (1.25 kg/cm 2 ) were found within acceptable range. The quantitative estimation of calcium by atomic absorbance spectrophotometry was carried out using ethanol-water solvent extraction method and found 76.27 ± 0.439 mg/tab of elemental calcium in optimized F4 formulation. Conclusion:The developed herbomineral formulation is suitable for calcium deficiency by balancing hormonal imbalance and increases the rate of ossification of bone which helps to curing bone fracture, osteoporosis and calcium deficiency related problems.

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“…3 Ayurvedic and herbal medicinal products contain a combination of number of chemical compounds that may give the anticipated activity in combination. 4 The development of a stable polyherbal formulation is a challenging task because of the large number of varied chemical compounds present in the different medicinal plants. Hence, the entire herbal drug or herbal drug preparation is regarded as active drug substance, regardless of whether constituents with defined therapeutic activity are known and unfortunately, the quality of a majority of them remains uncontrolled.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of herbal hepatoprotective formulation against paracetamol induced liver toxicity

Gupta¹,

Sheth²,

Pandey³

et al. 2013

Journal of Young Pharmacists

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a b s t r a c tAim: To isolate and identify the quercetin from polyherbal hepatoprotective formulation. Polyherbal formulations were developed by using five bioactive fractionated extracts of Butea monosperma, Bauhinia variegata and Ocimum gratissimum for treatment of liver disorders by exploiting the knowledge of traditional system of medicine and evaluated for hepatoprotective activity using acute liver toxicity model of paracetamol induced liver damage in rats. Methods: Major active fractions were isolated by solvent fractionation and quantified by HPTLC method. Two polyherbal tablet formulations were developed by the wet granulation method using microcrystalline cellulose, aerosil and other excipients and subjected for physicochemical evaluation to assess physical stability followed by pharmacological screening. The prepared tablets were finally subjected to stability testing to assess its shelf-life. The rats were monitored for change in liver morphology, biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP) and total bilirubin for polyherbal tablet formulation at 50 mg/kg and polyherbal tablet formulation at 100 mg/kg. Results: Active principle was isolated, quantified by HPTLC and characterized with IR. Both formulations showed significant hepatoprotective activity. The histological studies were also support the biochemical parameters. From the results of biochemical analysis and histopathological studies, it can be accomplished that polyherbal tablet formulation at 100 mg/kg can be effectively formulated into a suitable dosage form with added benefit of no side effects for control and cure of chronic ailments like liver disorders. A comparative histopathological study of liver exhibited almost normal architecture as compared to toxicant group. Conclusion: Biochemical marker showed improved results for polyherbal tablet formulation at 100 mg/ kg. Polyherbal tablet formulation contains a potent hepatoprotective agent suggested to be a flavone concentrated in polyherbal formulation which may find clinical application in amelioration of paracetamol induced liver damage.

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Design and development of a stable polyherbal formulation based on the results of compatibility studies

Cited by 35 publications

References 24 publications

Analytical Standards of Amrtadi Churna: A Classical Ayurvedic Formulation

Analytical Standards of Amrtadi Churna: A Classical Ayurvedic Formulation

Formulation of Polyherbomineral Matrices for Treatment of Osteoporosis

Design and evaluation of herbal hepatoprotective formulation against paracetamol induced liver toxicity

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