Design and Construction of Hybrid Microcapsules with Higher‐Order Structure and Multiple Functions

Abstract

The construction of inorganic‐protein hybrid microcapsules by using bovine serum albumin, metal ion clusters, and poly (N‐isopropylacrylamide) nanoconjugates as building blocks is presented. These microcapsules have robust membranes, which can keep their spherical morphology. They support interfacial catalytic activity by the ion clusters on their surface, and can be used as a platform to immobilize enzyme on the interface of oil/water to increase the diversity and efficiency of catalysis. These microcapsules also act as a container to make materials away from bacteria when existing silver clusters on the membrane. The obtained results highlight the construction of these microcompartments. These novel microcompartments can provide some new opportunities in bottom‐up synthetic biology, bioinspired microstorage/ microreactor, and drug/gene delivery in the future.

Emerging applications for living crystallization-driven self-assembly

“…They have diverse applications in areas such as microencapsulation, controlled release, and catalysis, and have also been investigated as synthetic protocells with membrane-gated enzyme reactivity. [261][262][263][264][265][266][267][268][269] The formation of colloidosomes was reported using fiber-like micelles of different length prepared via living CDSA as stabilisers of a water-in-oil Pickering emulsion. 254 The size- Figure 7a).…”

Surface Permeability of Membrane and Catalytic Performance Based on Redox-Responsive of Hybrid Hollow Polymeric Microcapsules

“…First, HPs were prepared by interfacial assembly of BSA-Au NCs-PNIPAAm conjugates at the water droplet/2-ethyl-1-hexanol (oil) interface according to our previously reported method ( Figure S1, Supporting Information ) [ 10 , 11 , 12 , 13 , 14 , 15 ]. The hollow HPs with the size ranging from 9 μm to 23 μm were generated throughout the whole process by using the BSA-Au NCs-PNIPAAM ( Figure 1 a).…”

Near-Infrared-Induced Contractile Proteinosome Microreactor with a Fast Control on Enzymatic Reactions

“…Compartmentalization is a process widely found in nature to limit, protect, and regulate biological processes and transport substances. − To date, various types of microcompartments with water cores surrounded by membrane domains have been developed with promising applications in the fields of nanoreactors, − materials science, , biomedicine, − and artificial cells. ,,, The reported microcompartments included polymersomes, ,− proteinosomes, − phospholipid vesicles, polypeptide capsules, organic and inorganic colloids, − hyperbranched polymer vesicles, and multicompartment vesicles. , Given that the molecular weight cutoff of the membrane is associated with controlling the passage of substances in and out of the interior core domain, which is also a prerequisite attribute in the design of microcompartment models, recently, the design and construction of stimulus-responsive microcompartments have been extensively studied. − One of the most effective methods is the application of stimulus-responsive polymers, a class of “smart” polymers that sense the smallest changes in the environment, usually pH, − light, temperature, enzymes, redox agents, ions, and gases . Installation force or electrochemistry results in a change in the physical or chemical structure of the assembly .…”