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Cited by 10 publications
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References 18 publications
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“…In vitro inhibitory activity data (% inhibition) of the phenyl substituted b-phenylethylidene hydrazine analogues on GABA-AT, reported by Sowa et al, 2005, was taken for study. Three-dimensional structures were drawn for each molecule and the molecular geometries optimized using Monte Carlo conformational search (Metropolis et al, 1953), MMF fields and charges.…”
Section: D-qsar Studiesmentioning
confidence: 99%
See 1 more Smart Citation
“…In vitro inhibitory activity data (% inhibition) of the phenyl substituted b-phenylethylidene hydrazine analogues on GABA-AT, reported by Sowa et al, 2005, was taken for study. Three-dimensional structures were drawn for each molecule and the molecular geometries optimized using Monte Carlo conformational search (Metropolis et al, 1953), MMF fields and charges.…”
Section: D-qsar Studiesmentioning
confidence: 99%
“…1) analogues, possessing a variety of substituents (Me, OMe, Cl, F and CF 3 ) at 2-, 3-and 4-positions of the phenyl ring was synthesized and evaluated as inhibitor for the GABA-AT. Preliminary in vitro screening for GABA-AT inhibition showed that all the analogues possessed activity against this enzyme (Sowa et al, 2005).…”
mentioning
confidence: 99%
“…In vitro inhibitory activity data (% inhibition) of the phenyl-substituted b-phenylethylidene hydrazine analogues on GABA-AT, reported by Sowa et al, 2005 was taken for study. GABA-AT activity was measured using the radiochemical procedure of Steri andFonnum, 1978 as modified by McManus et al, (1992).…”
Section: Datasetmentioning
confidence: 99%
“…A series of phenyl-ring-substituted PEH derivatives was synthesized and screened to study their effects on GABA metabolism (Sowa et al, 2005).…”
mentioning
confidence: 99%
“…Gamma amino butyrate amino transferase (GABA-AT) is a pyridoxal phosphate dependent enzyme mainly responsible for degradation of inhibitory neurotransmitter, gamma amino butyric acid. It is one of the most important targets in the design and discovery of successful antiepileptic drugs (Sowa et al, 2005). Automated flexible docking is an important emerging technology for rational lead discovery based on the receptor structure which is considered as rigid (Abagyan and Totrov, 2001).…”
Section: Introductionmentioning
confidence: 99%