Design, analysis and simulation for development of the first clinical micro-CT scanner1

Wang, Ge; Zhao, Shiying; Yu, Hengyong; Miller, Charles A.; Abbas, Paul J.; Gantz, Bruce J.; Lee, Seung Wook; Rubinstein, Jay T.

doi:10.1016/j.acra.2004.01.024

Cited by 36 publications

(32 citation statements)

References 27 publications

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“…Second, ultrafast tomography may enable clinical micro-CT such as for inner ear imaging. 15 Two major obstacles in achieving such fine spatial resolution in vivo are physiological motion induced blurring ͑the finer the image resolution, the more significant the physiological motion will be, which is in an order of a millimeter͒ and radiation dose concern ͑the finer the resolution, the much greater the radiation dose will be delivered to the patient͒. When the x-ray beams target a small ROI and projections are acquired in parallel, the above two issues are effectively addressed at the same time, which may help derive ultrafine features of interest ͑image-based biomarkers͒ for many applications of diagnosis and therapy.…”

Section: Fig 4 Multisource Interior Tomography Concept-mentioning

confidence: 99%

“…15,16 Although the multisource and multidetector configuration is a natural solution to high temporal resolution CT imaging and already used in the classic Mayo Clinic dynamic spatial reconstructor, 17,18 the modern Siemens dual-source cone-beam scanner, 19 and other tomographic systems, 20 x-ray source scanning remains indispensable. The bulkiness of the detectors in the limited physical space inside a CT gantry makes it impossible to collect a large number of projections simultaneously.…”

Section: Introductionmentioning

confidence: 99%

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A scheme for multisource interior tomography

Wang

2009

Med. Phys.

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Currently, x-ray computed tomography ͑CT͒ requires source scanning so that projections can be collected from various orientations for image reconstruction. Limited by the scanning time, the temporal resolution of CT is often inadequate when rapid dynamics is involved in an object to be reconstructed. To meet this challenge, here the authors propose a scheme of multisource interior tomography for ultrafast imaging that reconstructs a relatively small region of interest ͑ROI͒. Specifically, such a ROI is irradiated in parallel with narrow x-ray beams defined by many sourcedetector pairs for data acquisition. This ROI can be then reconstructed using the interior tomography approach. To demonstrate the merits of this approach, the authors report interior reconstruction from in vivo lung CT data at a much reduced radiation dose, which is roughly proportional to the ROI size. The results suggest a scheme for ultrafast tomography ͑such as with a limited number of sources and in a scanning mode͒ to shorten data acquisition time and to suppress motion blurring.

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Section: Fig 4 Multisource Interior Tomography Concept-mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A scheme for multisource interior tomography

Wang

2009

Med. Phys.

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“…Clinical CT scanners have relatively large FOV ͑up to 50 cm͒ and moderate spatial resolution ͑2-3 cycles/ mm͒ for whole body imaging. 1,2 Decreasing the object size has no effect on the resulting spatial resolution of clinical CT scanners. On the other hand, micro-CT scanners are appropriate for imaging small objects.…”

Section: Introductionmentioning

confidence: 99%

“…Such scanners have spatial resolution of up to 100 cycles/mm; they are, however, limited by the corresponding small FOV. 2,3 The newly introduced CT scanners, such as the variable resolution x-ray ͑VRX͒ CT, combine the advantages of both clinical and micro-CT scanners. This design provides the possibility to adjust the spatial resolution according to the object size.…”

Section: Introductionmentioning

confidence: 99%

Novel detector design for reducing intercell x‐ray cross‐talk in the variable resolution x‐ray CT scanner: A Monte Carlo study

Arabi

Kamali-Asl

et al. 2011

Medical Physics

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Purpose:The variable resolution x-ray ͑VRX͒ CT scanner provides substantial improvement in the spatial resolution by matching the scanner's field of view ͑FOV͒ to the size of the object being imaged. Intercell x-ray cross-talk is one of the most important factors limiting the spatial resolution of the VRX detector. In this work, a new cell arrangement in the VRX detector is suggested to decrease the intercell x-ray cross-talk. The idea is to orient the detector cells toward the opening end of the detector. Methods: Monte Carlo simulations were used for performance assessment of the oriented cell detector design. Previously published design parameters and simulation results of x-ray cross-talk for the VRX detector were used for model validation using the GATE Monte Carlo package. In the first step, the intercell x-ray cross-talk of the actual VRX detector model was calculated as a function of the FOV. The obtained results indicated an optimum cell orientation angle of 28°to minimize the x-ray cross-talk in the VRX detector. Thereafter, the intercell x-ray cross-talk in the oriented cell detector was modeled and quantified. Results:The intercell x-ray cross-talk in the actual detector model was considerably high, reaching up to 12% at FOVs from 24 to 38 cm. The x-ray cross-talk in the oriented cell detector was less than 5% for all possible FOVs, except 40 cm ͑maximum FOV͒. The oriented cell detector could provide considerable decrease in the intercell x-ray cross-talk for the VRX detector, thus leading to significant improvement in the spatial resolution and reduction in the spatial resolution nonuniformity across the detector length. Conclusions: The proposed oriented cell detector is the first dedicated detector design for the VRX CT scanners. Application of this concept to multislice and flat-panel VRX detectors would also result in higher spatial resolution.

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“…They also use high resolution x-ray detectors with pixel spacing smaller than 50 µm [31,54]. Modern micro-CT scanners usually employ CCD cameras or FPDs in a CBCT configuration [39,54,67,59] (see Section 2.1.2). Due to the small size of the samples, the x-ray photons used in micro-CT imaging are frequently of a lower energy (around 25 keV) than those used in clinical scanners where energies in excess of 50 keV are the norm [60].…”

Section: Micro-ct Scannersmentioning

confidence: 99%

Development and Application of Computational Tools for the Study and Optimization of Variable Resolution X-ray (VRX) Computed Tomography Scanners

Rendon¹

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Design, analysis and simulation for development of the first clinical micro-CT scanner1

Cited by 36 publications

References 27 publications

A scheme for multisource interior tomography

A scheme for multisource interior tomography

Novel detector design for reducing intercell x‐ray cross‐talk in the variable resolution x‐ray CT scanner: A Monte Carlo study

Development and Application of Computational Tools for the Study and Optimization of Variable Resolution X-ray (VRX) Computed Tomography Scanners

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