Desialylation by neuraminidases in platelets, kiss of death or bittersweet?
Nora Butta,
Dianne E. van der Wal
Abstract:Purpose of review
Loss of surface sialic acid by neuraminidases is known as ‘desialylation’. Platelets are desialylated in bacterial or viral infections, during storage, senescence, various mutations, platelet auto antibodies, hemostasis and shear stress. In this review the recent literature on the different sialic acid capped glycan structures will be covered as well as platelet desialylation in inherited glycan disorders and induced by external neuraminidases.
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